Seroatlas · Human Serome Atlas

VAPB

Vesicle-associated membrane protein-associated protein B/C

Also known as: ALS8, VAP-B, VAP-C, VAPB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95292
Gene
VAPB
Ensembl
ENSG00000124164
Chromosome
20
Canonical length
243 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Endoplasmic reticulum
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

243 residues, UniProt reviewed canonical sequence.

>O95292|VAPB
     1  MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR RYCVRPNSGI
    61  IDAGASINVS VMLQPFDYDP NEKSKHKFMV QSMFAPTDTS DMEAVWKEAK PEDLMDSKLR
   121  CVFELPAEND KPHDVEINKI ISTTASKTET PIVSKSLSSS LDDTEVKKVM EECKRLQGEV
   181  QRLREENKQF KEEDGLRMRK TVQSNSPISA LAPTGKEEGL STRLLALVVL FFIVGVIIGK
   241  IAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VAPB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 44 nTPM
  • tongue: 37 nTPM
  • adrenal gland: 36 nTPM
  • liver: 34 nTPM
  • spinal cord: 33 nTPM
  • cerebral cortex: 28 nTPM

Single-cell type

  • platelets: 209 nCPM
  • corticotrophs: 113 nCPM
  • somatotrophs: 107 nCPM
  • lactotrophs: 89 nCPM
  • renal collecting duct intercalated cells: 86 nCPM
  • myonuclei: 82 nCPM

Immune cell

  • naive CD8 T-cell: 4.8 nTPM
  • memory CD4 T-cell: 4.6 nTPM
  • MAIT T-cell: 4.5 nTPM
  • gdT-cell: 3.9 nTPM
  • neutrophil: 3.7 nTPM
  • NK-cell: 3.7 nTPM

Brain region

  • thalamus: 60 nTPM
  • spinal cord: 58 nTPM
  • pons: 56 nTPM
  • midbrain: 53 nTPM
  • medulla oblongata: 52 nTPM
  • hypothalamus: 52 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about VAPB.

Disease | AllUniProt

Conditions VAPB is implicated in, by any mechanism.

  • Amyotrophic lateral sclerosis 8 (ALS8) MIM:608627
  • Spinal muscular atrophy, proximal, adult, autosomal dominant (SMAPAD) MIM:182980

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 414 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Amyotrophic lateral sclerosis type 8
  • Adult-onset proximal spinal muscular atrophy, autosomal dominant

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0.58
gnomAD missense Z
1.25
DepMap mean gene effect
0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 20% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VAPB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VAPB as an antibody target. Whether an autoantibody or antibody against VAPB could matter depends on whether native VAPB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VAPB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VAPB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VAPB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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