Seroatlas · Human Serome Atlas

PITPNM1

Membrane-associated phosphatidylinositol transfer protein 1

Also known as: DRES9, NIR2, PITM1_HUMAN, PITPNM, Rd9, RDGB, RDGB1, RDGBA1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00562
Gene
PITPNM1
Ensembl
ENSG00000110697
Chromosome
11
Canonical length
1244 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

PITPNM1 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

1244 residues, UniProt reviewed canonical sequence.

>O00562|PITPNM1
     1  MLIKEYHILL PMSLDEYQVA QLYMIQKKSR EESSGEGSGV EILANRPYTD GPGGSGQYTH
    61  KVYHVGSHIP GWFRALLPKA ALQVEEESWN AYPYTRTRYT CPFVEKFSIE IETYYLPDGG
   121  QQPNVFNLSG AERRQRILDT IDIVRDAVAP GEYKAEEDPR LYHSVKTGRG PLSDDWARTA
   181  AQTGPLMCAY KLCKVEFRYW GMQAKIEQFI HDVGLRRVML RAHRQAWCWQ DEWTELSMAD
   241  IRALEEETAR MLAQRMAKCN TGSEGSEAQP PGKPSTEARS AASNTGTPDG PEAPPGPDAS
   301  PDASFGKQWS SSSRSSYSSQ HGGAVSPQSL SEWRMQNIAR DSENSSEEEF FDAHEGFSDS
   361  EEVFPKEMTK WNSNDFIDAF ASPVEAEGTP EPGAEAAKGI EDGAQAPRDS EGLDGAGELG
   421  AEACAVHALF LILHSGNILD SGPGDANSKQ ADVQTLSSAF EAVTRIHFPE ALGHVALRLV
   481  PCPPICAAAY ALVSNLSPYS HDGDSLSRSQ DHIPLAALPL LATSSSRYQG AVATVIARTN
   541  QAYSAFLRSP EGAGFCGQVA LIGDGVGGIL GFDALCHSAN AGTGSRGSSR RGSMNNELLS
   601  PEFGPVRDPL ADGVEGLGRG SPEPSALPPQ RIPSDMASPE PEGSQNSLQA APATTSSWEP
   661  RRASTAFCPP AASSEAPDGP SSTARLDFKV SGFFLFGSPL GLVLALRKTV MPALEAAQMR
   721  PACEQIYNLF HAADPCASRL EPLLAPKFQA IAPLTVPRYQ KFPLGDGSSL LLADTLQTHS
   781  SLFLEELEML VPSTPTSTSG AFWKGSELAT DPPAQPAAPS TTSEVVKILE RWWGTKRIDY
   841  SLYCPEALTA FPTVTLPHLF HASYWESADV VAFILRQVIE KERPQLAECE EPSIYSPAFP
   901  REKWQRKRTQ VKIRNVTSNH RASDTVVCEG RPQVLSGRFM YGPLDVVTLT GEKVDVYIMT
   961  QPLSGKWIHF GTEVTNSSGR LTFPVPPERA LGIGVYPVRM VVRGDHTYAE CCLTVVARGT
  1021  EAVVFSIDGS FTASVSIMGS DPKVRAGAVD VVRHWQDSGY LIVYVTGRPD MQKHRVVAWL
  1081  SQHNFPHGVV SFCDGLTHDP LRQKAMFLQS LVQEVELNIV AGYGSPKDVA VYAALGLSPS
  1141  QTYIVGRAVR KLQAQCQFLS DGYVAHLGQL EAGSHSHASS GPPRAALGKS SYGVAAPVDF
  1201  LRKQSQLLRS RGPSQAEREG PGTPPTTLAR GKARSISLKL DSEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PITPNM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 45 nTPM
  • retina: 38 nTPM
  • cerebellum: 38 nTPM
  • hypothalamus: 32 nTPM
  • amygdala: 32 nTPM
  • kidney: 29 nTPM

Single-cell type

  • fallopian tube ciliated cells: 78 nCPM
  • endometrial ciliated cells: 74 nCPM
  • respiratory ciliated cells: 71 nCPM
  • epididymal efferent duct ciliated cells: 50 nCPM
  • colonocytes: 44 nCPM
  • enterocytes: 40 nCPM

Immune cell

  • intermediate monocyte: 3.3 nTPM
  • non-classical monocyte: 2.7 nTPM
  • classical monocyte: 1.4 nTPM
  • neutrophil: 1.4 nTPM
  • gdT-cell: 1.1 nTPM
  • total PBMC: 1.1 nTPM

Brain region

  • thalamus: 159 nTPM
  • midbrain: 116 nTPM
  • hypothalamus: 99 nTPM
  • cerebral cortex: 96 nTPM
  • amygdala: 91 nTPM
  • choroid plexus: 78 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PITPNM1.

Disease | ImmuneIEDB

Conditions an epitope on PITPNM1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0
gnomAD missense Z
3.19
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PITPNM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PITPNM1 as an antibody target. Whether an autoantibody or antibody against PITPNM1 could matter depends on whether native PITPNM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PITPNM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PITPNM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PITPNM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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