Seroatlas · Human Serome Atlas

AFTPH

Aftiphilin

Also known as: AFTIN_HUMAN, FLJ20080, FLJ23793, MGC33965, Nbla10388

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ULP2
Gene: AFTPH
Ensembl: ENSG00000119844
Chromosome: 2
Canonical length: 936 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles,Cytosol

OverviewNCBI Gene

Enables clathrin binding activity. Predicted to be involved in intracellular transport. Located in Golgi apparatus; cytosol; and nucleoplasm. Part of AP-1 adaptor complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

936 residues, UniProt reviewed canonical sequence.

>Q6ULP2|AFTPH
     1  MEPDIIRMYS SSPPPLDNGA EDDDDDEFGE FGGFSEVSPS GVGFVDFDTP DYTRPKEEFV
    61  PSNHFMPIHE FSENVDSLTS FKSIKNGNDK DITAELSAPV KGQSDVLLST TSKEIISSEM
   121  LATSIDGMER PGNLNKVVEQ RQNVGTLESF SPGDFRTNMN VVHQNKQLES CNGEKPPCLE
   181  ILTNGFAVLE TVNPQGTDDL DNVADSKGRK PLSTHSTEYN LDSVPSPAEE FADFATFSKK
   241  ERIQLEEIEC AVLNDREALT IRENNKINRV NELNSVKEVA LGRSLDNKGD TDGEDQVCVS
   301  EISIVTNRGF SVEKQGLPTL QQDEFLQSGV QSKAWSLVDS ADNSEAIRRE QCKTEEKLDL
   361  LTSKCAHLCM DSVKTSDDEV GSPKEESRKF TNFQSPNIDP TEENDLDDSL SVKNGDSSND
   421  FVTCNDINED DFGDFGDFGS ASGSTPPFVT GTQDSMSDAT FEESSEHFPH FSEPGDDFGE
   481  FGDINAVSCQ EETILTKSDL KQTSDNLSEE CQLARKSSGT GTEPVAKLKN GQEGEIGHFD
   541  SVPNIQDDCN GFQDSDDFAD FSSAGPSQVV DWNAFEDEQK DSCSWAAFGD QQATESHHRK
   601  EAWQSHRTDE NIDTPGTPKT HSVPSATSKG AVASGHLQES ATSVQTALLN RLERIFEACF
   661  PSILVPDAEE EVTSLKHLLE TSTLPIKTRE ALPESGELLD VWTELQDIHD AHGLRYQWGG
   721  SHSNKKLLSS LGIDTRNILF TGNKKQPVIV PMYAAGLGML EPTKEPLKPL SAAEKIASIG
   781  QTATMSPDMN TCTSDQFQES LPPVQFDWSS SGLTNPLDAS GGSTLLNLDF FGPVDDSSSS
   841  SSTTIPGVDP ELYELTTSKL EISTSSLKVT DAFARLMSTV EKTSTSTRKP KREEHLSEEA
   901  IKVIAGLPDL TFMHAKVLMF PATLTPSTSS QEKADG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AFTPH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

kidney: 43 nTPM
tonsil: 33 nTPM
parathyroid gland: 32 nTPM
stomach: 28 nTPM
prostate: 27 nTPM
retina: 27 nTPM

Single-cell type

neutrophils: 597 nCPM
neutrophil progenitors: 299 nCPM
suprabasal keratinocytes: 226 nCPM
basal keratinocytes: 221 nCPM
monocytes: 203 nCPM
b-cells: 187 nCPM

Immune cell

basophil: 26 nTPM
memory B-cell: 17 nTPM
naive B-cell: 17 nTPM
neutrophil: 14 nTPM
eosinophil: 13 nTPM
plasmacytoid DC: 13 nTPM

Brain region

cerebellum: 33 nTPM
choroid plexus: 25 nTPM
cerebral cortex: 22 nTPM
hypothalamus: 22 nTPM
white matter: 22 nTPM
midbrain: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.14
gnomAD pLI: 1
gnomAD missense Z: 0.69
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein transport

Molecular functions

clathrin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AFTPH in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AFTPH as an antibody target. Whether an autoantibody or antibody against AFTPH could matter depends on whether native AFTPH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AFTPH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AFTPH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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