Seroatlas · Human Serome Atlas

OSBPL6

Oxysterol-binding protein-related protein 6

Also known as: ORP6, OSBL6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZF3
Gene: OSBPL6
Ensembl: ENSG00000079156
Chromosome: 2
Canonical length: 934 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

934 residues, UniProt reviewed canonical sequence.

>Q9BZF3|OSBPL6
     1  MSSDEKGISP AHKTSTPTHR SASSSTSSQR DSRQSIHILE RTASSSTEPS VSRQLLEPEP
    61  VPLSKEADSW EIIEGLKIGQ TNVQKPDKHE GFMLKKRKWP LKGWHKRFFV LDNGMLKYSK
   121  APLDIQKGKV HGSIDVGLSV MSIKKKARRI DLDTEEHIYH LKVKSQDWFD AWVSKLRHHR
   181  LYRQNEIVRS PRDASFHIFP STSTAESSPA ANVSVMDGKM QPNSFPWQSP LPCSNSLPAT
   241  CTTGQSKVAA WLQDSEEMDR CAEDLAHCQS NLVELSKLLQ NLEILQRTQS APNFTDMQAN
   301  CVDISKKDKR VTRRWRTKSV SKDTKIQLQV PFSATMSPVR LHSSNPNLCA DIEFQTPPSH
   361  LTDPLESSTD YTKLQEEFCL IAQKVHSLLK SAFNSIAIEK EKLKQMVSEQ DHSKGHSTQM
   421  ARLRQSLSQA LNQNAELRSR LNRIHSESII CDQVVSVNII PSPDEAGEQI HVSLPLSQQV
   481  ANESRLSMSE SVSEFFDAQE VLLSASSSEN EASDDESYIS DVSDNISEDN TSVADNISRQ
   541  ILNGELTGGA FRNGRRACLP APCPDTSNIN LWNILRNNIG KDLSKVSMPV ELNEPLNTLQ
   601  HLCEEMEYSE LLDKASETDD PYERMVLVAA FAVSGYCSTY FRAGSKPFNP VLGETYECIR
   661  EDKGFRFFSE QVSHHPPISA CHCESKNFVF WQDIRWKNKF WGKSMEILPV GTLNVMLPKY
   721  GDYYVWNKVT TCIHNILSGR RWIEHYGEVT IRNTKSSVCI CKLTFVKVNY WNSNMNEVQG
   781  VVIDQEGKAV YRLFGKWHEG LYCGVAPSAK CIWRPGSMPT NYELYYGFTR FAIELNELDP
   841  VLKDLLPPTD ARFRPDQRFL EEGNLEAAAS EKQRVEELQR SRRRYMEENN LEHIPKFFKK
   901  VIDANQREAW VSNDTYWELR KDPGFSKVDS PVLW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OSBPL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 31 nTPM
tongue: 19 nTPM
cerebral cortex: 8.6 nTPM
skin: 8.3 nTPM
retina: 7.8 nTPM
pituitary gland: 6.2 nTPM

Single-cell type

thymic myoid cells: 1,097 nCPM
myonuclei: 665 nCPM
pituicytes/fscs: 527 nCPM
respiratory ciliated cells: 382 nCPM
astrocytes: 367 nCPM
retinal ganglion cells: 359 nCPM

Immune cell

neutrophil: 0.3 nTPM
naive CD4 T-cell: 0.2 nTPM
MAIT T-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
total PBMC: 0.1 nTPM

Brain region

cerebral cortex: 48 nTPM
hypothalamus: 32 nTPM
white matter: 31 nTPM
thalamus: 30 nTPM
midbrain: 29 nTPM
hippocampal formation: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.2
gnomAD pLI: 1
gnomAD missense Z: 1.78
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OSBPL6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OSBPL6 as an antibody target. Whether an autoantibody or antibody against OSBPL6 could matter depends on whether native OSBPL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OSBPL6 is annotated at the cell surface, where native OSBPL6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OSBPL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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