Seroatlas · Human Serome Atlas

OSBPL10

Oxysterol-binding protein-related protein 10

Also known as: OSB10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXB5
Gene: OSBPL10
Ensembl: ENSG00000144645
Chromosome: 3
Canonical length: 764 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

764 residues, UniProt reviewed canonical sequence.

>Q9BXB5|OSBPL10
     1  MERAVQGTDG GGGSNSSSRS SSRATSAGSS PSCSLAGRGV SSRSAAAGLG GGGSRSSPGS
    61  VAASPSGGGG RRREPALEGV LSKYTNLLQG WQNRYFVLDF EAGILQYFVN EQSKHQKPRG
   121  VLSLSGAIVS LSDEAPHMLV VYSANGEMFK LRAADAKEKQ FWVTQLRACA KYHMEMNSKS
   181  APSSRSRSLT LLPHGTPNSA SPCSQRHLSV GAPGVVTITH HKSPAAARRA KSQYSGQLHE
   241  VREMMNQVEG QQKNLVHAIE SLPGSGPLTA LDQDLLLLKA TSAATLSCLG ECLNLLQQSV
   301  HQAGQPSQKP GASENILGWH GSKSHSTEQL KNGTLGSLPS ASANITWAIL PNSAEDEQTS
   361  QPEPEPNSGS ELVLSEDEKS DNEDKEETEL GVMEDQRSII LHLISQLKLG MDLTKVVLPT
   421  FILEKRSLLE MYADFMAHPD LLLAITAGAT PEERVICFVE YYLTAFHEGR KGALAKKPYN
   481  PIIGETFHCS WEVPKDRVKP KRTASRSPAS CHEHPMADDP SKSYKLRFVA EQVSHHPPIS
   541  CFYCECEEKR LCVNTHVWTK SKFMGMSVGV SMIGEGVLRL LEHGEEYVFT LPSAYARSIL
   601  TIPWVELGGK VSINCAKTGY SATVIFHTKP FYGGKVHRVT AEVKHNPTNT IVCKAHGEWN
   661  GTLEFTYNNG ETKVIDTTTL PVYPKKIRPL EKQGPMESRN LWREVTRYLR LGDIDAATEQ
   721  KRHLEEKQRV EERKRENLRT PWKPKYFIQE GDGWVYFNPL WKAH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OSBPL10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

urinary bladder: 24 nTPM
testis: 24 nTPM
placenta: 21 nTPM
seminal vesicle: 20 nTPM
tonsil: 17 nTPM
kidney: 13 nTPM

Single-cell type

late spermatids: 1,990 nCPM
pituitary stem cells: 892 nCPM
b-cells: 724 nCPM
early spermatids: 656 nCPM
sertoli cells: 650 nCPM
corticotrophs: 513 nCPM

Immune cell

memory B-cell: 12 nTPM
naive B-cell: 6.8 nTPM
neutrophil: 0.5 nTPM
basophil: 0.2 nTPM
total PBMC: 0.2 nTPM
eosinophil: 0.1 nTPM

Brain region

choroid plexus: 22 nTPM
cerebral cortex: 18 nTPM
midbrain: 17 nTPM
basal ganglia: 14 nTPM
pons: 14 nTPM
hypothalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0
gnomAD missense Z: 0.87
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OSBPL10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OSBPL10 as an antibody target. Whether an autoantibody or antibody against OSBPL10 could matter depends on whether native OSBPL10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OSBPL10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OSBPL10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...