Seroatlas · Human Serome Atlas

RMDN3

Regulator of microtubule dynamics protein 3

Also known as: FAM82A2, FAM82C, FLJ10579, PTPIP51, RMD3, RMD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96TC7
Gene: RMDN3
Ensembl: ENSG00000137824
Chromosome: 15
Canonical length: 470 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytokinetic bridge,Mitochondria

OverviewNCBI Gene

Enables microtubule binding activity. Involved in intracellular calcium ion homeostasis. Located in several cellular components, including intercellular bridge; mitochondrial outer membrane; and spindle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

470 residues, UniProt reviewed canonical sequence.

>Q96TC7|RMDN3
     1  MSRLGALGGA RAGLGLLLGT AAGLGFLCLL YSQRWKRTQR HGRSQSLPNS LDYTQTSDPG
    61  RHVMLLRAVP GGAGDASVLP SLPREGQEKV LDRLDFVLTS LVALRREVEE LRSSLRGLAG
   121  EIVGEVRCHM EENQRVARRR RFPFVRERSD STGSSSVYFT ASSGATFTDA ESEGGYTTAN
   181  AESDNERDSD KESEDGEDEV SCETVKMGRK DSLDLEEEAA SGASSALEAG GSSGLEDVLP
   241  LLQQADELHR GDEQGKREGF QLLLNNKLVY GSRQDFLWRL ARAYSDMCEL TEEVSEKKSY
   301  ALDGKEEAEA ALEKGDESAD CHLWYAVLCG QLAEHESIQR RIQSGFSFKE HVDKAIALQP
   361  ENPMAHFLLG RWCYQVSHLS WLEKKTATAL LESPLSATVE DALQSFLKAE ELQPGFSKAG
   421  RVYISKCYRE LGKNSEARWW MKLALELPDV TKEDLAIQKD LEELEVILRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RMDN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

small intestine: 49 nTPM
spinal cord: 47 nTPM
amygdala: 45 nTPM
cerebral cortex: 45 nTPM
midbrain: 42 nTPM
hippocampal formation: 42 nTPM

Single-cell type

enterocytes: 101 nCPM
syncytiotrophoblasts: 93 nCPM
oocytes: 83 nCPM
erythrocyte progenitors: 75 nCPM
cytotrophoblasts: 72 nCPM
differentiating spermatogonia: 69 nCPM

Immune cell

NK-cell: 65 nTPM
plasmacytoid DC: 54 nTPM
gdT-cell: 28 nTPM
total PBMC: 27 nTPM
memory CD8 T-cell: 26 nTPM
MAIT T-cell: 25 nTPM

Brain region

thalamus: 61 nTPM
white matter: 54 nTPM
medulla oblongata: 54 nTPM
basal ganglia: 53 nTPM
midbrain: 50 nTPM
cerebellum: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0
gnomAD missense Z: 0.39
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RMDN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RMDN3 as an antibody target. Whether an autoantibody or antibody against RMDN3 could matter depends on whether native RMDN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RMDN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RMDN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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