VAMP1
Vesicle-associated membrane protein 1
Also known as: SYB1, VAMP-1, VAMP1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P23763
- Gene
- VAMP1
- Ensembl
- ENSG00000139190
- Chromosome
- 12
- Canonical length
- 118 aa
- Protein class
- Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters
OverviewNCBI Gene
Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014]
Canonical amino-acid sequenceUniProt
118 residues, UniProt reviewed canonical sequence.
>P23763|VAMP1
1 MSAPAQPPAE GTEGTAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIIRV NVDKVLERDQ
61 KLSELDDRAD ALQAGASQFE SSAAKLKRKY WWKNCKMMIM LGAICAIIVV VIVIYFFTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against VAMP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.56
- Highest tissue expression
- 109 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 109 nTPM
- spinal cord: 97 nTPM
- midbrain: 85 nTPM
- hypothalamus: 72 nTPM
- bone marrow: 60 nTPM
- hippocampal formation: 43 nTPM
Single-cell type
- tuft cells: 35 nCPM
- neutrophils: 25 nCPM
- neutrophil progenitors: 22 nCPM
- adrenal medulla cells: 21 nCPM
- adrenal cortex cells: 21 nCPM
- oligodendrocytes: 19 nCPM
Immune cell
- eosinophil: 14 nTPM
- basophil: 9.1 nTPM
- T-reg: 6.9 nTPM
- gdT-cell: 5.9 nTPM
- memory CD8 T-cell: 5.7 nTPM
- naive CD4 T-cell: 5.1 nTPM
Brain region
- medulla oblongata: 369 nTPM
- cerebral cortex: 333 nTPM
- pons: 319 nTPM
- thalamus: 182 nTPM
- cerebellum: 175 nTPM
- spinal cord: 158 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about VAMP1.
Disease | AllUniProt
Conditions VAMP1 is implicated in, by any mechanism.
- Spastic ataxia 1, autosomal dominant (SPAX1) MIM:108600
- Myasthenic syndrome, congenital, 25, presynaptic (CMS25) MIM:618323
Disease | GeneticClinVar
14 pathogenic / likely-pathogenic of 147 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Spastic paraplegia
- Myasthenic syndrome, congenital, 25, presynaptic
- Spastic ataxia 1
- VAMP1-related disorder
- Houge-Janssens syndrome 2
Disease | ImmuneIEDB
Conditions an epitope on VAMP1 was assayed in.
- chronic lymphocytic leukemia T cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.15
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.23
- DepMap mean gene effect
- 0.07
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of VAMP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads VAMP1 as an antibody target. Whether an autoantibody or antibody against VAMP1 could matter depends on whether native VAMP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
VAMP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label VAMP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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