Seroatlas · Human Serome Atlas

STARD3NL

STARD3 N-terminal-like protein

Also known as: MENTHO, MGC3251, STR3N_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95772
Gene: STARD3NL
Ensembl: ENSG00000010270
Chromosome: 7
Canonical length: 234 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Vesicles
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a late-endosomal protein that contains a conserved MENTAL (MLN64 N-terminal) domain. The encoded protein binds cholesterol molecules and may play a role in endosomal cholesterol transport through interactions with metastatic lymph node protein 64 (MLN64). [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

234 residues, UniProt reviewed canonical sequence.

>O95772|STARD3NL
     1  MNHLPEDMEN ALTGSQSSHA SLRNIHSINP TQLMARIESY EGREKKGISD VRRTFCLFVT
    61  FDLLFVTLLW IIELNVNGGI ENTLEKEVMQ YDYYSSYFDI FLLAVFRFKV LILAYAVCRL
   121  RHWWAIALTT AVTSAFLLAK VILSKLFSQG AFGYVLPIIS FILAWIETWF LDFKVLPQEA
   181  EEENRLLIVQ DASERAALIP GGLSDGQFYS PPESEAGSEE AEEKQDSEKP LLEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STARD3NL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 47 nTPM
hypothalamus: 47 nTPM
midbrain: 47 nTPM
placenta: 46 nTPM
prostate: 38 nTPM
amygdala: 36 nTPM

Single-cell type

early spermatids: 149 nCPM
late spermatids: 149 nCPM
platelets: 147 nCPM
extravillous trophoblasts: 133 nCPM
prostatic glandular cells: 112 nCPM
kupffer cells: 111 nCPM

Immune cell

NK-cell: 71 nTPM
eosinophil: 56 nTPM
neutrophil: 53 nTPM
gdT-cell: 52 nTPM
total PBMC: 47 nTPM
non-classical monocyte: 47 nTPM

Brain region

pons: 65 nTPM
midbrain: 61 nTPM
hypothalamus: 56 nTPM
white matter: 52 nTPM
medulla oblongata: 50 nTPM
spinal cord: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0
gnomAD missense Z: 0.78
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STARD3NL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STARD3NL as an antibody target. Whether an autoantibody or antibody against STARD3NL could matter depends on whether native STARD3NL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STARD3NL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STARD3NL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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