Seroatlas · Human Serome Atlas

OSBPL11

Oxysterol-binding protein-related protein 11

Also known as: FLJ13012, FLJ13164, ORP-11, ORP11, OSB11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXB4
Gene: OSBPL11
Ensembl: ENSG00000144909
Chromosome: 3
Canonical length: 747 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

747 residues, UniProt reviewed canonical sequence.

>Q9BXB4|OSBPL11
     1  MQGGEPVSTM KVSESEGKLE GQATAVTPNK NSSCGGGISS SSSSRGGSAK GWQYSDHMEN
    61  VYGYLMKYTN LVTGWQYRFF VLNNEAGLLE YFVNEQSRNQ KPRGTLQLAG AVISPSDEDS
   121  HTFTVNAASG EQYKLRATDA KERQHWVSRL QICTQHHTEA IGKNNPPLKS RSFSLASSSN
   181  SPISQRRPSQ NAISFFNVGH SKLQSLSKRT NLPPDHLVEV REMMSHAEGQ QRDLIRRIEC
   241  LPTSGHLSSL DQDLLMLKAT SMATMNCLND CFHILQLQHA SHQKGSLPSG TTIEWLEPKI
   301  SLSNHYKNGA DQPFATDQSK PVAVPEEQPV AESGLLAREP EEINADDEIE DTCDHKEDDL
   361  GAVEEQRSVI LHLLSQLKLG MDLTRVVLPT FILEKRSLLE MYADFMSHPD LFIAITNGAT
   421  AEDRMIRFVE YYLTSFHEGR KGAIAKKPYN PIIGETFHCS WKMPKSEVAS SVFSSSSTQG
   481  VTNHAPLSGE SLTQVGSDCY TVRFVAEQVS HHPPVSGFYA ECTERKMCVN AHVWTKSKFL
   541  GMSIGVTMVG EGILSLLEHG EEYTFSLPCA YARSILTVPW VELGGKVSVN CAKTGYSASI
   601  TFHTKPFYGG KLHRVTAEVK HNITNTVVCR VQGEWNSVLE FTYSNGETKY VDLTKLAVTK
   661  KRVRPLEKQD PFESRRLWKN VTDSLRESEI DKATEHKHTL EERQRTEERH RTETGTPWKT
   721  KYFIKEGDGW VYHKPLWKII PTTQPAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OSBPL11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

tongue: 75 nTPM
skeletal muscle: 52 nTPM
liver: 27 nTPM
spleen: 15 nTPM
lung: 13 nTPM
parathyroid gland: 13 nTPM

Single-cell type

myonuclei: 255 nCPM
neutrophils: 242 nCPM
kupffer cells: 199 nCPM
microglia: 186 nCPM
sertoli cells: 161 nCPM
astrocytes: 157 nCPM

Immune cell

neutrophil: 18 nTPM
basophil: 17 nTPM
myeloid DC: 15 nTPM
classical monocyte: 12 nTPM
intermediate monocyte: 12 nTPM
non-classical monocyte: 10 nTPM

Brain region

hypothalamus: 33 nTPM
midbrain: 30 nTPM
basal ganglia: 27 nTPM
medulla oblongata: 26 nTPM
thalamus: 26 nTPM
white matter: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.83
gnomAD missense Z: 2.29
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

sterol binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OSBPL11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OSBPL11 as an antibody target. Whether an autoantibody or antibody against OSBPL11 could matter depends on whether native OSBPL11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OSBPL11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OSBPL11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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