Seroatlas · Human Serome Atlas

PRKACA

cAMP-dependent protein kinase catalytic subunit alpha

Also known as: KAPCA_HUMAN, PKACa

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P17612
Gene
PRKACA
Ensembl
ENSG00000072062
Chromosome
19
Canonical length
351 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Microtubules,Cytokinetic bridge,Primary cilium,Basal body,Cytosol

OverviewNCBI Gene

This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

351 residues, UniProt reviewed canonical sequence.

>P17612|PRKACA
     1  MGNAAAAKKG SEQESVKEFL AKAKEDFLKK WESPAQNTAH LDQFERIKTL GTGSFGRVML
    61  VKHKETGNHY AMKILDKQKV VKLKQIEHTL NEKRILQAVN FPFLVKLEFS FKDNSNLYMV
   121  MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ IVLTFEYLHS LDLIYRDLKP ENLLIDQQGY
   181  IQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF
   241  ADQPIQIYEK IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVN DIKNHKWFAT
   301  TDWIAIYQRK VEAPFIPKFK GPGDTSNFDD YEEEEIRVSI NEKCGKEFSE F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRKACA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
276 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 276 nTPM
  • heart muscle: 191 nTPM
  • adrenal gland: 118 nTPM
  • tongue: 115 nTPM
  • ovary: 92 nTPM
  • blood vessel: 80 nTPM

Single-cell type

  • other brain neurons: 43 nCPM
  • microglia: 37 nCPM
  • brain excitatory neurons: 35 nCPM
  • brain inhibitory neurons: 32 nCPM
  • bergmann glia: 25 nCPM
  • astrocytes: 24 nCPM

Immune cell

  • neutrophil: 3.3 nTPM
  • intermediate monocyte: 2.7 nTPM
  • non-classical monocyte: 2.5 nTPM
  • classical monocyte: 1.5 nTPM
  • myeloid DC: 1.1 nTPM
  • gdT-cell: 0.8 nTPM

Brain region

  • medulla oblongata: 97 nTPM
  • cerebral cortex: 96 nTPM
  • pons: 95 nTPM
  • midbrain: 93 nTPM
  • hypothalamus: 89 nTPM
  • thalamus: 83 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRKACA.

Disease | AllUniProt

Conditions PRKACA is implicated in, by any mechanism.

  • Primary pigmented nodular adrenocortical disease 4 (PPNAD4) MIM:615830
  • Cardioacrofacial dysplasia 1 (CAFD1) MIM:619142

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 79 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Pigmented nodular adrenocortical disease, primary, 4
  • ACTH-independent adrenal Cushing syndrome, somatic
  • Adrenal cortex neoplasm
  • Cardioacrofacial dysplasia 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.97
gnomAD missense Z
2.97
DepMap mean gene effect
-0.24
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRKACA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRKACA as an antibody target. Whether an autoantibody or antibody against PRKACA could matter depends on whether native PRKACA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRKACA is annotated at the cell surface, where native PRKACA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PRKACA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRKACA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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