Seroatlas · Human Serome Atlas

OSBPL3

Oxysterol-binding protein-related protein 3

Also known as: KIAA0704, ORP-3, ORP3, OSBL3_HUMAN, OSBP3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H4L5
Gene: OSBPL3
Ensembl: ENSG00000070882
Chromosome: 7
Canonical length: 887 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoli,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. The encoded protein is involved in the regulation of cell adhesion and organization of the actin cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

887 residues, UniProt reviewed canonical sequence.

>Q9H4L5|OSBPL3
     1  MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE PPVQKGFLLK
    61  KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID VGLSVMSVKK SSKCIDLDTE
   121  EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN EIAMFPHEVN HFFSGSTITD SSSGVFDSIS
   181  SRKRSSISKQ NLFQTGSNVS FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL
   241  QSMDVLHRTY SAPAINAIQG GSFESPKKEK RSHRRWRSRA IGKDAKGTLQ VPKPFSGPVR
   301  LHSSNPNLST LDFGEEKNYS DGSETSSEFS KMQEDLCHIA HKVYFTLRSA FNIMSAEREK
   361  LKQLMEQDAS SSPSAQVIGL KNALSSALAQ NTDLKERLRR IHAESLLLDS PAVAKSGDNL
   421  AEENSRDENR ALVHQLSNES RLSITDSLSE FFDAQEVLLS PSSSENEISD DDSYVSDISD
   481  NLSLDNLSND LDNERQTLGP VLDSGREAKS RRRTCLPAPC PSSSNISLWN ILRNNIGKDL
   541  SKVAMPVELN EPLNTLQRLC EELEYSELLD KAAQIPSPLE RMVYVAAFAI SAYASSYYRA
   601  GSKPFNPVLG ETYECIREDK GFQFFSEQVS HHPPISACHA ESRNFVFWQD VRWKNKFWGK
   661  SMEIVPIGTT HVTLPVFGDH FEWNKVTSCI HNILSGQRWI EHYGEIVIKN LHDDSCYCKV
   721  NFIKAKYWST NAHEIEGTVF DRSGKAVHRL FGKWHESIYC GGGSSSACVW RANPMPKGYE
   781  QYYSFTQFAL ELNEMDPSSK SLLPPTDTRF RPDQRFLEEG NLEEAEIQKQ RIEQLQRERR
   841  RVLEENHVEH QPRFFRKSDD DSWVSNGTYL ELRKDLGFSK LDHPVLW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OSBPL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

tonsil: 14 nTPM
parathyroid gland: 13 nTPM
kidney: 13 nTPM
urinary bladder: 12 nTPM
lymph node: 11 nTPM
skin: 9.7 nTPM

Single-cell type

distal convoluted tubule cells: 602 nCPM
plasma cells: 481 nCPM
loop of henle epithelial cells: 471 nCPM
renal collecting duct intercalated cells: 443 nCPM
endometrial ciliated cells: 336 nCPM
renal connecting tubule cells: 317 nCPM

Immune cell

T-reg: 9.6 nTPM
gdT-cell: 8.5 nTPM
NK-cell: 7.7 nTPM
MAIT T-cell: 7.3 nTPM
basophil: 5.8 nTPM
memory CD8 T-cell: 5.6 nTPM

Brain region

cerebral cortex: 13 nTPM
white matter: 11 nTPM
hypothalamus: 11 nTPM
thalamus: 11 nTPM
basal ganglia: 9.2 nTPM
choroid plexus: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0
gnomAD missense Z: 1.18
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

bile acid biosynthetic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OSBPL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OSBPL3 as an antibody target. Whether an autoantibody or antibody against OSBPL3 could matter depends on whether native OSBPL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OSBPL3 is annotated at the cell surface, where native OSBPL3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OSBPL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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