Seroatlas · Human Serome Atlas

MIGA2

Mitoguardin 2

Also known as: C9orf54, FAM73B, FLJ00199, FLJ14596, MIGA2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7L4E1
Gene
MIGA2
Ensembl
ENSG00000148343
Chromosome
9
Canonical length
593 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Cell Junctions,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables protein heterodimerization activity and protein homodimerization activity. Involved in mitochondrial fusion. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

593 residues, UniProt reviewed canonical sequence.

>Q7L4E1|MIGA2
     1  MAFRRAEGTS MIQALAMTVA EIPVFLYTTF GQSAFSQLRL TPGLRKVLFA TALGTVALAL
    61  AAHQLKRRRR RKKQVGPEMG GEQLGTVPLP ILLARKVPSV KKGYSSRRVQ SPSSKSNDTL
   121  SGISSIEPSK HSGSSHSVAS MMAVNSSSPT AACSGLWDAR GMEESLTTSD GNAESLYMQG
   181  MELFEEALQK WEQALSVGQR GDSGSTPMPR DGLRNPETAS EPLSEPESQR KEFAEKLESL
   241  LHRAYHLQEE FGSTFPADSM LLDLERTLML PLTEGSLRLR ADDEDSLTSE DSFFSATELF
   301  ESLQTGDYPI PLSRPAAAYE EALQLVKEGR VPCRTLRTEL LGCYSDQDFL AKLHCVRQAF
   361  EGLLEDKSNQ LFFGKVGRQM VTGLMTKAEK SPKGFLESYE EMLSYALRPE TWATTRLELE
   421  GRGVVCMSFF DIVLDFILMD AFEDLENPPA SVLAVLRNRW LSDSFKETAL ATACWSVLKA
   481  KRRLLMVPDG FISHFYSVSE HVSPVLAFGF LGPKPQLAEV CAFFKHQIVQ YLRDMFDLDN
   541  VRYTSLPALA DDILQLSRRR SEILLGYLGV PAASSAGVNG ALPRENGPLG ELQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MIGA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 17 nTPM
  • heart muscle: 16 nTPM
  • small intestine: 15 nTPM
  • bone marrow: 14 nTPM
  • skeletal muscle: 9.6 nTPM
  • tongue: 7.9 nTPM

Single-cell type

  • platelets: 125 nCPM
  • esophageal apical cells: 48 nCPM
  • enterocytes: 46 nCPM
  • erythrocyte progenitors: 41 nCPM
  • colonocytes: 36 nCPM
  • foveolar cells: 33 nCPM

Immune cell

  • basophil: 7.7 nTPM
  • MAIT T-cell: 3.6 nTPM
  • neutrophil: 2.7 nTPM
  • plasmacytoid DC: 2.3 nTPM
  • memory CD8 T-cell: 2.2 nTPM
  • intermediate monocyte: 1.9 nTPM

Brain region

  • medulla oblongata: 23 nTPM
  • thalamus: 20 nTPM
  • pons: 20 nTPM
  • cerebellum: 19 nTPM
  • hypothalamus: 19 nTPM
  • midbrain: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MIGA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MIGA2 as an antibody target. Whether an autoantibody or antibody against MIGA2 could matter depends on whether native MIGA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MIGA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MIGA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MIGA2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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