Seroatlas · Human Serome Atlas

OSBP

Oxysterol-binding protein 1

Also known as: OSBP1, OSBP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P22059
Gene: OSBP
Ensembl: ENSG00000110048
Chromosome: 11
Canonical length: 807 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol
Quaternary structure: Homotrimer

OverviewNCBI Gene

Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

807 residues, UniProt reviewed canonical sequence.

>P22059|OSBP
     1  MAATELRGVV GPGPAAIAAL GGGGAGPPVV GGGGGRGDAG PGSGAASGTV VAAAAGGPGP
    61  GAGGVAAAGP APAPPTGGSG GSGAGGSGSA REGWLFKWTN YIKGYQRRWF VLSNGLLSYY
   121  RSKAEMRHTC RGTINLATAN ITVEDSCNFI ISNGGAQTYH LKASSEVERQ RWVTALELAK
   181  AKAVKMLAES DESGDEESVS QTDKTELQNT LRTLSSKVED LSTCNDLIAK HGTALQRSLS
   241  ELESLKLPAE SNEKIKQVNE RATLFRITSN AMINACRDFL MLAQTHSKKW QKSLQYERDQ
   301  RIRLEETLEQ LAKQHNHLER AFRGATVLPA NTPGNVGSGK DQCCSGKGDM SDEDDENEFF
   361  DAPEIITMPE NLGHKRTGSN ISGASSDISL DEQYKHQLEE TKKEKRTRIP YKPNYSLNLW
   421  SIMKNCIGKE LSKIPMPVNF NEPLSMLQRL TEDLEYHELL DRAAKCENSL EQLCYVAAFT
   481  VSSYSTTVFR TSKPFNPLLG ETFELDRLEE NGYRSLCEQV SHHPPAAAHH AESKNGWTLR
   541  QEIKITSKFR GKYLSIMPLG TIHCIFHATG HHYTWKKVTT TVHNIIVGKL WIDQSGEIDI
   601  VNHKTGDKCN LKFVPYSYFS RDVARKVTGE VTDPSGKVHF ALLGTWDEKM ECFKVQPVIG
   661  ENGGDARQRG HEAEESRVML WKRNPLPKNA ENMYYFSELA LTLNAWESGT APTDSRLRPD
   721  QRLMENGRWD EANAEKQRLE EKQRLSRKKR EAEAMKATED GTPYDPYKAL WFERKKDPVT
   781  KELTHIYRGE YWECKEKQDW SSCPDIF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OSBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

liver: 55 nTPM
skeletal muscle: 54 nTPM
adrenal gland: 43 nTPM
parathyroid gland: 42 nTPM
tongue: 41 nTPM
kidney: 40 nTPM

Single-cell type

neutrophils: 140 nCPM
myonuclei: 129 nCPM
adrenal cortex cells: 127 nCPM
epididymal principal cells: 115 nCPM
hepatocytes: 112 nCPM
breast lactating cells: 104 nCPM

Immune cell

plasmacytoid DC: 4 nTPM
memory CD4 T-cell: 2.9 nTPM
gdT-cell: 2.8 nTPM
MAIT T-cell: 2.6 nTPM
naive CD4 T-cell: 2.6 nTPM
memory CD8 T-cell: 2.3 nTPM

Brain region

choroid plexus: 36 nTPM
pons: 33 nTPM
midbrain: 33 nTPM
thalamus: 31 nTPM
hypothalamus: 30 nTPM
medulla oblongata: 30 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about OSBP.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 101 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Short stature

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 1
gnomAD missense Z: 3.59
DepMap mean gene effect: -0.44
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

bile acid biosynthetic process
ceramide transport
intracellular cholesterol transport
lipid transport
phospholipid transport
positive regulation of insulin secretion involved in cellular response to glucose stimulus
sphingomyelin biosynthetic process
sterol transport
positive regulation of secretory granule organization

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OSBP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OSBP as an antibody target. Whether an autoantibody or antibody against OSBP could matter depends on whether native OSBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OSBP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OSBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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