OSBPL9

Protein identityUniProt · HPA

UniProt accession

Q96SU4

Gene

OSBPL9

Ensembl

ENSG00000117859

Chromosome

1

Canonical length

736 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This family member functions as a cholesterol transfer protein that regulates Golgi structure and function. Multiple transcript variants, most of which encode distinct isoforms, have been identified. Related pseudogenes have been identified on chromosomes 3, 11 and 12. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

736 residues, UniProt reviewed canonical sequence.

>Q96SU4|OSBPL9
     1  MASIMEGPLS KWTNVMKGWQ YRWFVLDYNA GLLSYYTSKD KMMRGSRRGC VRLRGAVIGI
    61  DDEDDSTFTI TVDQKTFHFQ ARDADEREKW IHALEETILR HTLQLQGLDS GFVPSVQDFD
   121  KKLTEADAYL QILIEQLKLF DDKLQNCKED EQRKKIETLK ETTNSMVESI KHCIVLLQIA
   181  KDQSNAEKHA DGMISTINPV DAIYQPSPLE PVISTMPSQT VLPPEPVQLC KSEQRPSSLP
   241  VGPVLATLGH HQTPTPNSTG SGHSPPSSSL TSPSHVNLSP NTVPEFSYSS SEDEFYDADE
   301  FHQSGSSPKR LIDSSGSASV LTHSSSGNSL KRPDTTESLN SSLSNGTSDA DLFDSHDDRD
   361  DDAEAGSVEE HKSVIMHLLS QVRLGMDLTK VVLPTFILER RSLLEMYADF FAHPDLFVSI
   421  SDQKDPKDRM VQVVKWYLSA FHAGRKGSVA KKPYNPILGE IFQCHWTLPN DTEENTELVS
   481  EGPVPWVSKN SVTFVAEQVS HHPPISAFYA ECFNKKIQFN AHIWTKSKFL GMSIGVHNIG
   541  QGCVSCLDYD EHYILTFPNG YGRSILTVPW VELGGECNIN CSKTGYSANI IFHTKPFYGG
   601  KKHRITAEIF SPNDKKSFCS IEGEWNGVMY AKYATGENTV FVDTKKLPII KKKVRKLEDQ
   661  NEYESRSLWK DVTFNLKIRD IDAATEAKHR LEERQRAEAR ERKEKEIQWE TRLFHEDGEC
   721  WVYDEPLLKR LGAAKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OSBPL9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

67 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.31

gnomAD pLI

0.98

gnomAD missense Z

2.66

DepMap mean gene effect

-0.18

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• bile acid biosynthetic process
• intermembrane lipid transfer

Molecular functions

• sterol binding
• sterol transfer activity

Cellular components

• cytosol
• Golgi apparatus
• late endosome membrane
• membrane
• protein-containing complex
• transporter complex

Protein domainsUniProt · Pfam · InterPro

• Oxysterol-binding protein
• Pleckstrin homology domain
• PH-like domain superfamily
• Oxysterol-binding protein, conserved site
• Oxysterol-binding protein superfamily
• PH domain
• Oxysterol-binding protein

KeywordsUniProt

• Acetylation
• Endosome
• Golgi apparatus
• Lipid transport
• Lipid-binding
• Membrane
• Phosphoprotein
• Transport

InteractionsUniProt · HPA

Protein binding partners of OSBPL9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• OSBPL10
• OSBPL11
• VAPA
• VAPB