Seroatlas · Human Serome Atlas

FAM83G

Protein FAM83G

Also known as: FA83G_HUMAN, FLJ41564, PAWS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6ND36
Gene: FAM83G
Ensembl: ENSG00000188522
Chromosome: 17
Canonical length: 823 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable protein kinase binding activity. Involved in BMP signaling pathway. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

823 residues, UniProt reviewed canonical sequence.

>A6ND36|FAM83G
     1  MAFSQVQCLD DNHVNWRSSE SKPEFFYSEE QRLALEALVA RGRDAFYEVL KRENIRDFLS
    61  ELELKRILET IEVYDPGSED PRGTGPSQGP EDNGVGDGEE ASGADGVPIE AEPLPSLEYW
   121  PQKSDRSIPQ LDLGWPDTIA YRGVTRASVY MQPPIDGQAH IKEVVRKMIS QAQKVIAVVM
   181  DMFTDVDIFK DLLDAGFKRK VAVYIIVDES NVKYFLHMCE RACMHLGHLK NLRVRSSGGT
   241  EFFTRSATKF KGALAQKFMF VDGDRAVCGS YSFTWSAART DRNVISVLSG QVVEMFDRQF
   301  QELYLMSHSV SLKGIPMEKE PEPEPIVLPS VVPLVPAGTV AKKLVNPKYA LVKAKSVDEI
   361  AKISSEKQEA KKPLGLKGPA LAEHPGELPE LLPPIHPGLL HLERANMFEY LPTWVEPDPE
   421  PGSDILGYIN IIDPNIWNPQ PSQMNRIKIR DTSQASAQHQ LWKQSQDSRP RPEPCPPPEP
   481  SAPQDGVPAE NGLPQGDPEP LPPVPKPRTV PVADVLARDS SDIGWVLELP KEEAPQNGTD
   541  HRLPRMAGPG HAPLQRQLSV TQDDPESLGV GLPNGLDGVE EEDDDDYVTL SDQDSHSGSS
   601  GRGPGPRRPS VASSVSEEYF EVREHSVPLR RRHSEQVANG PTPPPRRQLS APHITRGTFV
   661  GPQGGSPWAQ SRGREEADAL KRMQAQRSTD KEAQGQQFHH HRVPASGTRD KDGFPGPPRY
   721  RSAADSVQSS TRNAGPAMAG PHHWQAKGGQ VPRLLPDPGS PRLAQNARPM TDGRATEEHP
   781  SPFGIPYSKL SQSKHLKART GGSQWASSDS KRRAQAPRDR KDP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM83G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

skin: 65 nTPM
esophagus: 50 nTPM
liver: 21 nTPM
heart muscle: 17 nTPM
vagina: 17 nTPM
cervix: 12 nTPM

Single-cell type

esophageal suprabasal cells: 106 nCPM
suprabasal keratinocytes: 93 nCPM
basal keratinocytes: 80 nCPM
esophageal apical cells: 77 nCPM
esophageal basal cells: 59 nCPM
ocular epithelial cells: 51 nCPM

Immune cell

basophil: 1.1 nTPM
gdT-cell: 0.7 nTPM
T-reg: 0.5 nTPM
memory CD4 T-cell: 0.4 nTPM
MAIT T-cell: 0.3 nTPM
memory B-cell: 0.3 nTPM

Brain region

pons: 5.1 nTPM
choroid plexus: 3.6 nTPM
hypothalamus: 3.3 nTPM
medulla oblongata: 2.5 nTPM
midbrain: 2.3 nTPM
thalamus: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0
gnomAD missense Z: 1.4
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

BMP signaling pathway

Molecular functions

protein kinase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM83G in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM83G as an antibody target. Whether an autoantibody or antibody against FAM83G could matter depends on whether native FAM83G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM83G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM83G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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