Seroatlas · Human Serome Atlas

PLEKHA3

Pleckstrin homology domain-containing family A member 3

Also known as: FAPP1, PKHA3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HB20
Gene
PLEKHA3
Ensembl
ENSG00000116095
Chromosome
2
Canonical length
300 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

Enables identical protein binding activity and phosphatidylinositol-4-phosphate binding activity. Predicted to be involved in endosome organization; receptor recycling; and retrograde transport, endosome to Golgi. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

300 residues, UniProt reviewed canonical sequence.

>Q9HB20|PLEKHA3
     1  MEGVLYKWTN YLTGWQPRWF VLDNGILSYY DSQDDVCKGS KGSIKMAVCE IKVHSADNTR
    61  MELIIPGEQH FYMKAVNAAE RQRWLVALGS SKACLTDTRT KKEKEISETS ESLKTKMSEL
   121  RLYCDLLMQQ VHTIQEFVHH DENHSSPSAE NMNEASSLLS ATCNTFITTL EECVKIANAK
   181  FKPEMFQLHH PDPLVSPVSP SPVQMMKRSV SHPGSCSSER SSHSIKEPVS TLHRLSQRRR
   241  RTYSDTDSCS DIPLEDPDRP VHCSKNTLNG DLASATIPEE SRLMAKKQSE SEDTLPSFSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
9.3 nTPM

Expression across tissuesHPA

Tissue

  • testis: 9.3 nTPM
  • retina: 7.4 nTPM
  • adrenal gland: 6.2 nTPM
  • heart muscle: 5.9 nTPM
  • epididymis: 5.8 nTPM
  • bone marrow: 5.1 nTPM

Single-cell type

  • late spermatids: 739 nCPM
  • early spermatids: 196 nCPM
  • late primary spermatocytes: 125 nCPM
  • smooth muscle cells: 101 nCPM
  • parietal cells: 94 nCPM
  • epididymal principal cells: 90 nCPM

Immune cell

  • naive B-cell: 1.5 nTPM
  • NK-cell: 0.8 nTPM
  • memory CD4 T-cell: 0.7 nTPM
  • neutrophil: 0.6 nTPM
  • plasmacytoid DC: 0.6 nTPM
  • basophil: 0.5 nTPM

Brain region

  • cerebellum: 19 nTPM
  • choroid plexus: 17 nTPM
  • cerebral cortex: 15 nTPM
  • white matter: 15 nTPM
  • basal ganglia: 15 nTPM
  • midbrain: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PLEKHA3.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 27 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0.02
gnomAD missense Z
1.41
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLEKHA3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEKHA3 as an antibody target. Whether an autoantibody or antibody against PLEKHA3 could matter depends on whether native PLEKHA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEKHA3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLEKHA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLEKHA3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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