Seroatlas · Human Serome Atlas

TSG101

Tumor susceptibility gene 101 protein

Also known as: TS101_HUMAN, TSG10, VPS23

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99816
Gene
TSG101
Ensembl
ENSG00000074319
Chromosome
11
Canonical length
390 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoli,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

390 residues, UniProt reviewed canonical sequence.

>Q99816|TSG101
     1  MAVSESQLKK MVSKYKYRDL TVRETVNVIT LYKDLKPVLD SYVFNDGSSR ELMNLTGTIP
    61  VPYRGNTYNI PICLWLLDTY PYNPPICFVK PTSSMTIKTG KHVDANGKIY LPYLHEWKHP
   121  QSDLLGLIQV MIVVFGDEPP VFSRPISASY PPYQATGPPN TSYMPGMPGG ISPYPSGYPP
   181  NPSGYPGCPY PPGGPYPATT SSQYPSQPPV TTVGPSRDGT ISEDTIRASL ISAVSDKLRW
   241  RMKEEMDRAQ AELNALKRTE EDLKKGHQKL EEMVTRLDQE VAEVDKNIEL LKKKDEELSS
   301  ALEKMENQSE NNDIDEVIIP TAPLYKQILN LYAEENAIED TIFYLGEALR RGVIDLDVFL
   361  KHVRLLSRKQ FQLRALMQKA RKTAGLSDLY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSG101 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
94 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 94 nTPM
  • tongue: 78 nTPM
  • esophagus: 67 nTPM
  • kidney: 66 nTPM
  • heart muscle: 64 nTPM
  • choroid plexus: 63 nTPM

Single-cell type

  • oocytes: 580 nCPM
  • esophageal apical cells: 437 nCPM
  • syncytiotrophoblasts: 407 nCPM
  • neutrophils: 364 nCPM
  • cytotrophoblasts: 251 nCPM
  • early primary spermatocytes: 214 nCPM

Immune cell

  • basophil: 189 nTPM
  • eosinophil: 156 nTPM
  • neutrophil: 124 nTPM
  • non-classical monocyte: 115 nTPM
  • total PBMC: 91 nTPM
  • T-reg: 85 nTPM

Brain region

  • white matter: 37 nTPM
  • choroid plexus: 37 nTPM
  • hypothalamus: 34 nTPM
  • spinal cord: 33 nTPM
  • cerebellum: 31 nTPM
  • medulla oblongata: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0.34
gnomAD missense Z
2
DepMap mean gene effect
-1.16
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSG101 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSG101 as an antibody target. Whether an autoantibody or antibody against TSG101 could matter depends on whether native TSG101 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSG101 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSG101 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TSG101. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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