Seroatlas · Human Serome Atlas

VPS37C

Vacuolar protein sorting-associated protein 37C

Also known as: FLJ20847, VP37C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A5D8V6
Gene: VPS37C
Ensembl: ENSG00000167987
Chromosome: 11
Canonical length: 355 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Vesicles,Primary cilium

OverviewNCBI Gene

VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

355 residues, UniProt reviewed canonical sequence.

>A5D8V6|VPS37C
     1  METLKDKTLQ ELEELQNDSE AIDQLALESP EVQDLQLERE MALATNRSLA ERNLEFQGPL
    61  EISRSNLSDR YQELRKLVER CQEQKAKLEK FSSALQPGTL LDLLQVEGMK IEEESEAMAE
   121  KFLEGEVPLE TFLENFSSMR MLSHLRRVRV EKLQEVVRKP RASQELAGDA PPPRPPPPVR
   181  PVPQGTPPVV EEQPQPPLAM PPYPLPYSPS PSLPVGPTAH GALPPAPFPV VSQPSFYSGP
   241  LGPTYPAAQL GPRGAAGYSW SPQRSMPPRP GYPGTPMGAS GPGYPLRGGR APSPGYPQQS
   301  PYPATGGKPP YPIQPQLPSF PGQPQPSVPL QPPYPPGPAP PYGFPPPPGP AWPGY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VPS37C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

stomach: 28 nTPM
pancreas: 25 nTPM
skeletal muscle: 24 nTPM
esophagus: 23 nTPM
blood vessel: 22 nTPM
skin: 22 nTPM

Single-cell type

rod photoreceptor cells: 164 nCPM
cone photoreceptor cells: 64 nCPM
monocytes: 50 nCPM
esophageal apical cells: 50 nCPM
syncytiotrophoblasts: 50 nCPM
neutrophils: 47 nCPM

Immune cell

neutrophil: 3.8 nTPM
intermediate monocyte: 2.6 nTPM
non-classical monocyte: 2.4 nTPM
eosinophil: 1.7 nTPM
classical monocyte: 1.4 nTPM
myeloid DC: 1 nTPM

Brain region

hippocampal formation: 24 nTPM
thalamus: 23 nTPM
medulla oblongata: 23 nTPM
choroid plexus: 23 nTPM
cerebral cortex: 22 nTPM
midbrain: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0.04
gnomAD missense Z: -0.01
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

calcium-dependent protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VPS37C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VPS37C as an antibody target. Whether an autoantibody or antibody against VPS37C could matter depends on whether native VPS37C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VPS37C is annotated at the cell surface, where native VPS37C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VPS37C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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