Seroatlas · Human Serome Atlas

VPS37B

Vacuolar protein sorting-associated protein 37B

Also known as: FLJ12750, VP37B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H9H4
Gene: VPS37B
Ensembl: ENSG00000139722
Chromosome: 12
Canonical length: 285 aa
Protein class: Predicted intracellular proteins
Subcellular location: Primary cilium,Cytosol

OverviewNCBI Gene

Enables calcium-dependent protein binding activity. Predicted to be involved in protein targeting to membrane; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Located in endosome membrane; midbody; and plasma membrane. Part of ESCRT I complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

285 residues, UniProt reviewed canonical sequence.

>Q9H9H4|VPS37B
     1  MAGAGSEARF AGLSLVQLNE LLEDEGQLTE MVQKMEETQN VQLNKEMTLA SNRSLAEGNL
    61  LYQPQLDTLK ARLTQKYQEL QVLFEAYQIK KTKLDRQSSS ASLETLLALL QAEGAKIEED
   121  TENMAEKFLD GELPLDSFID VYQSKRKLAH MRRVKIEKLQ EMVLKGQRLP QALAPLPPRL
   181  PELAPTAPLP YPAPEASGPP AVAPRRIPPP PPPVPAGRLA TPFTAAMSSG QAVPYPGLQC
   241  PPLPPRVGLP TQQGFSSQFV SPYPPPLPQR PPPRLPPHQP GFILQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VPS37B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 69 nTPM

Expression across tissuesHPA

Tissue

esophagus: 69 nTPM
bone marrow: 44 nTPM
stomach: 40 nTPM
salivary gland: 39 nTPM
spleen: 37 nTPM
adrenal gland: 33 nTPM

Single-cell type

esophageal apical cells: 356 nCPM
neutrophils: 317 nCPM
endometrial glandular cells: 244 nCPM
endometrial luminal cells: 210 nCPM
nk-cells: 203 nCPM
urothelial cells: 194 nCPM

Immune cell

neutrophil: 28 nTPM
gdT-cell: 14 nTPM
naive B-cell: 13 nTPM
basophil: 12 nTPM
eosinophil: 10 nTPM
memory B-cell: 10 nTPM

Brain region

hippocampal formation: 44 nTPM
amygdala: 41 nTPM
cerebral cortex: 41 nTPM
choroid plexus: 41 nTPM
white matter: 36 nTPM
medulla oblongata: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.06
gnomAD missense Z: -0.18
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

calcium-dependent protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VPS37B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VPS37B as an antibody target. Whether an autoantibody or antibody against VPS37B could matter depends on whether native VPS37B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VPS37B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VPS37B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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