Seroatlas · Human Serome Atlas

UBAP1

Ubiquitin-associated protein 1

Also known as: UBAP, UBAP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZ09
Gene: UBAP1
Ensembl: ENSG00000165006
Chromosome: 9
Canonical length: 502 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Canonical amino-acid sequenceUniProt

502 residues, UniProt reviewed canonical sequence.

>Q9NZ09|UBAP1
     1  MASKKLGADF HGTFSYLDDV PFKTGDKFKT PAKVGLPIGF SLPDCLQVVR EVQYDFSLEK
    61  KTIEWAEEIK KIEEAEREAE CKIAEAEAKV NSKSGPEGDS KMSFSKTHST ATMPPPINPI
   121  LASLQHNSIL TPTRVSSSAT KQKVLSPPHI KADFNLADFE CEEDPFDNLE LKTIDEKEEL
   181  RNILVGTTGP IMAQLLDNNL PRGGSGSVLQ DEEVLASLER ATLDFKPLHK PNGFITLPQL
   241  GNCEKMSLSS KVSLPPIPAV SNIKSLSFPK LDSDDSNQKT AKLASTFHST SCLRNGTFQN
   301  SLKPSTQSSA SELNGHHTLG LSALNLDSGT EMPALTSSQM PSLSVLSVCT EESSPPNTGP
   361  TVTPPNFSVS QVPNMPSCPQ AYSELQMLSP SERQCVETVV NMGYSYECVL RAMKKKGENI
   421  EQILDYLFAH GQLCEKGFDP LLVEEALEMH QCSEEKMMEF LQLMSKFKEM GFELKDIKEV
   481  LLLHNNDQDN ALEDLMARAG AS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 124 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 124 nTPM
skeletal muscle: 105 nTPM
esophagus: 68 nTPM
tongue: 67 nTPM
adrenal gland: 54 nTPM
liver: 50 nTPM

Single-cell type

neutrophils: 2,090 nCPM
esophageal apical cells: 820 nCPM
endometrial glandular cells: 487 nCPM
neutrophil progenitors: 460 nCPM
monocytes: 447 nCPM
ocular epithelial cells: 406 nCPM

Immune cell

neutrophil: 121 nTPM
eosinophil: 67 nTPM
MAIT T-cell: 66 nTPM
total PBMC: 55 nTPM
T-reg: 53 nTPM
classical monocyte: 51 nTPM

Brain region

thalamus: 59 nTPM
pons: 58 nTPM
cerebral cortex: 56 nTPM
medulla oblongata: 56 nTPM
midbrain: 55 nTPM
hypothalamus: 55 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UBAP1.

Disease | AllUniProt

Conditions UBAP1 is implicated in, by any mechanism.

Spastic paraplegia 80, autosomal dominant (SPG80) MIM:618418

Disease | GeneticClinVar

21 pathogenic / likely-pathogenic of 129 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Spastic paraplegia 80, autosomal dominant
Hereditary spastic paraplegia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.91
gnomAD missense Z: 0.87
DepMap mean gene effect: -0.84
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBAP1 as an antibody target. Whether an autoantibody or antibody against UBAP1 could matter depends on whether native UBAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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