Seroatlas · Human Serome Atlas

CEP55

Centrosomal protein of 55 kDa

Also known as: C10orf3, CEP55_HUMAN, CT111, FLJ10540

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q53EZ4
Gene
CEP55
Ensembl
ENSG00000138180
Chromosome
10
Canonical length
464 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Plasma membrane,Midbody,Primary cilium,Centriolar satellite,Cytosol,Connecting piece,Principal piece
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables identical protein binding activity. Involved in cranial skeletal system development; establishment of protein localization; and midbody abscission. Acts upstream of or within mitotic cytokinesis. Located in Flemming body and centrosome. Implicated in multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

464 residues, UniProt reviewed canonical sequence.

>Q53EZ4|CEP55
     1  MSSRSTKDLI KSKWGSKPSN SKSETTLEKL KGEIAHLKTS VDEITSGKGK LTDKERHRLL
    61  EKIRVLEAEK EKNAYQLTEK DKEIQRLRDQ LKARYSTTTL LEQLEETTRE GERREQVLKA
   121  LSEEKDVLKQ QLSAATSRIA ELESKTNTLR LSQTVAPNCF NSSINNIHEM EIQLKDALEK
   181  NQQWLVYDQQ REVYVKGLLA KIFELEKKTE TAAHSLPQQT KKPESEGYLQ EEKQKCYNDL
   241  LASAKKDLEV ERQTITQLSF ELSEFRRKYE ETQKEVHNLN QLLYSQRRAD VQHLEDDRHK
   301  TEKIQKLREE NDIARGKLEE EKKRSEELLS QVQFLYTSLL KQQEEQTRVA LLEQQMQACT
   361  LDFENEKLDR QHVQHQLHVI LKELRKARNQ ITQLESLKQL HEFAITEPLV TFQGETENRE
   421  KVAASPKSPT AALNESLVEC PKCNIQYPAT EHRDLLVHVE YCSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP55 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 26 nTPM
  • testis: 20 nTPM
  • tonsil: 15 nTPM
  • lymph node: 14 nTPM
  • rectum: 8.3 nTPM
  • appendix: 7.2 nTPM

Single-cell type

  • monocyte progenitors: 150 nCPM
  • late primary spermatocytes: 101 nCPM
  • early primary spermatocytes: 39 nCPM
  • gastric progenitor cells: 35 nCPM
  • megakaryocyte progenitors: 31 nCPM
  • esophageal basal cells: 27 nCPM

Immune cell

  • T-reg: 1.3 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • thalamus: 1 nTPM
  • pons: 0.6 nTPM
  • white matter: 0.3 nTPM
  • medulla oblongata: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CEP55.

Disease | AllUniProt

Conditions CEP55 is implicated in, by any mechanism.

  • Multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly (MARCH) MIM:236500

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 136 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Multinucleated neurons-anhydramnios-renal dysplasia-cerebellar hypoplasia-hydranencephaly syndrome
  • Inborn genetic diseases
  • CEP55-related disorder
  • Abnormality of prenatal development or birth

Disease | ImmuneIEDB

Conditions an epitope on CEP55 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
0.5
DepMap mean gene effect
-0.35
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP55 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP55 as an antibody target. Whether an autoantibody or antibody against CEP55 could matter depends on whether native CEP55 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP55 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP55 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CEP55. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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