Seroatlas · Human Serome Atlas

VPS37A

Vacuolar protein sorting-associated protein 37A

Also known as: FLJ32642, HCRP1, PQBP2, SPG53, VP37A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NEZ2
Gene
VPS37A
Ensembl
ENSG00000155975
Chromosome
8
Canonical length
397 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Centrosome,Cytosol,Acrosome,Equatorial segment,Perinuclear theca,Flagellar centriole,Mid piece,Principal piece,End piece

OverviewNCBI Gene

This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

397 residues, UniProt reviewed canonical sequence.

>Q8NEZ2|VPS37A
     1  MSWLFPLTKS ASSSAAGSPG GLTSLQQQKQ RLIESLRNSH SSIAEIQKDV EYRLPFTINN
    61  LTININILLP PQFPQEKPVI SVYPPIRHHL MDKQGVYVTS PLVNNFTMHS DLGKIIQSLL
   121  DEFWKNPPVL APTSTAFPYL YSNPSGMSPY ASQGFPFLPP YPPQEANRSI TSLSVADTVS
   181  SSTTSHTTAK PAAPSFGVLS NLPLPIPTVD ASIPTSQNGF GYKMPDVPDA FPELSELSVS
   241  QLTDMNEQEE VLLEQFLTLP QLKQIITDKD DLVKSIEELA RKNLLLEPSL EAKRQTVLDK
   301  YELLTQMKST FEKKMQRQHE LSESCSASAL QARLKVAAHE AEEESDNIAE DFLEGKMEID
   361  DFLSSFMEKR TICHCRRAKE EKLQQAIAMH SQFHAPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VPS37A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • retina: 51 nTPM
  • skeletal muscle: 39 nTPM
  • heart muscle: 34 nTPM
  • parathyroid gland: 32 nTPM
  • testis: 30 nTPM
  • tongue: 29 nTPM

Single-cell type

  • epicardial cells: 162 nCPM
  • syncytiotrophoblasts: 158 nCPM
  • late primary spermatocytes: 149 nCPM
  • esophageal apical cells: 120 nCPM
  • rod photoreceptor cells: 117 nCPM
  • oocytes: 106 nCPM

Immune cell

  • basophil: 34 nTPM
  • NK-cell: 24 nTPM
  • neutrophil: 18 nTPM
  • classical monocyte: 17 nTPM
  • MAIT T-cell: 17 nTPM
  • eosinophil: 17 nTPM

Brain region

  • cerebellum: 76 nTPM
  • white matter: 54 nTPM
  • basal ganglia: 48 nTPM
  • cerebral cortex: 46 nTPM
  • hypothalamus: 45 nTPM
  • thalamus: 44 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about VPS37A.

Disease | AllUniProt

Conditions VPS37A is implicated in, by any mechanism.

  • Spastic paraplegia 53, autosomal recessive (SPG53) MIM:614898

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 260 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hereditary spastic paraplegia 53

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0
gnomAD missense Z
-0.88
DepMap mean gene effect
-0.58
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VPS37A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VPS37A as an antibody target. Whether an autoantibody or antibody against VPS37A could matter depends on whether native VPS37A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VPS37A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VPS37A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VPS37A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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