Seroatlas · Human Serome Atlas

SCAMP3

Secretory carrier-associated membrane protein 3

Also known as: C1orf3, SCAM3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14828
Gene: SCAMP3
Ensembl: ENSG00000116521
Chromosome: 1
Canonical length: 347 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Vesicles

OverviewNCBI Gene

This gene encodes an integral membrane protein that belongs to the secretory carrier membrane protein family. The encoded protein functions as a carrier to the cell surface in post-golgi recycling pathways. This protein is also involved in protein trafficking in endosomal pathways. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

347 residues, UniProt reviewed canonical sequence.

>O14828|SCAMP3
     1  MAQSRDGGNP FAEPSELDNP FQDPAVIQHR PSRQYATLDV YNPFETREPP PAYEPPAPAP
    61  LPPPSAPSLQ PSRKLSPTEP KNYGSYSTQA SAAAATAELL KKQEELNRKA EELDRREREL
   121  QHAALGGTAT RQNNWPPLPS FCPVQPCFFQ DISMEIPQEF QKTVSTMYYL WMCSTLALLL
   181  NFLACLASFC VETNNGAGFG LSILWVLLFT PCSFVCWYRP MYKAFRSDSS FNFFVFFFIF
   241  FVQDVLFVLQ AIGIPGWGFS GWISALVVPK GNTAVSVLML LVALLFTGIA VLGIVMLKRI
   301  HSLYRRTGAS FQKAQQEFAA GVFSNPAVRT AAANAAAGAA ENAFRAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCAMP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 80 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 80 nTPM
adrenal gland: 59 nTPM
heart muscle: 56 nTPM
skin: 50 nTPM
spinal cord: 46 nTPM
pancreas: 45 nTPM

Single-cell type

oligodendrocytes: 28 nCPM
bergmann glia: 23 nCPM
oligodendrocyte progenitor cells: 21 nCPM
microglia: 21 nCPM
astrocytes: 20 nCPM
renal collecting duct principal cells: 18 nCPM

Immune cell

plasmacytoid DC: 103 nTPM
T-reg: 101 nTPM
naive B-cell: 101 nTPM
total PBMC: 101 nTPM
memory B-cell: 99 nTPM
gdT-cell: 95 nTPM

Brain region

white matter: 16 nTPM
cerebral cortex: 13 nTPM
basal ganglia: 13 nTPM
spinal cord: 12 nTPM
medulla oblongata: 12 nTPM
cerebellum: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0
gnomAD missense Z: 0.38
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 16% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin protein ligase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCAMP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCAMP3 as an antibody target. Whether an autoantibody or antibody against SCAMP3 could matter depends on whether native SCAMP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCAMP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCAMP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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