Seroatlas · Human Serome Atlas

MGRN1

E3 ubiquitin-protein ligase MGRN1

Also known as: KIAA0544, MGRN1_HUMAN, RNF156

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60291
Gene
MGRN1
Ensembl
ENSG00000102858
Chromosome
16
Canonical length
552 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum,Vesicles

OverviewNCBI Gene

Enables ubiquitin-protein transferase activity. Involved in endosome to lysosome transport; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; and protein monoubiquitination. Located in several cellular components, including early endosome; endoplasmic reticulum; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

552 residues, UniProt reviewed canonical sequence.

>O60291|MGRN1
     1  MGSILSRRIA GVEDIDIQAN SAYRYPPKSG NYFASHFFMG GEKFDTPHPE GYLFGENMDL
    61  NFLGSRPVQF PYVTPAPHEP VKTLRSLVNI RKDSLRLVRY KDDADSPTED GDKPRVLYSL
   121  EFTFDADARV AITIYCQASE EFLNGRAVYS PKSPSLQSET VHYKRGVSQQ FSLPSFKIDF
   181  SEWKDDELNF DLDRGVFPVV IQAVVDEGDV VEVTGHAHVL LAAFEKHMDG SFSVKPLKQK
   241  QIVDRVSYLL QEIYGIENKN NQETKPSDDE NSDNSNECVV CLSDLRDTLI LPCRHLCLCT
   301  SCADTLRYQA NNCPICRLPF RALLQIRAVR KKPGALSPVS FSPVLAQSLE HDEHSCPFKK
   361  SKPHPASLAS KKPKRETNSD SVPPGYEPIS LLEALNGLRA VSPAIPSAPL YEEITYSGIS
   421  DGLSQASCPL AAIDHILDSS RQKGRPQSKA PDSTLRSPSS PIHEEDEEKL SEDVDAPPPL
   481  GGAELALRES SSPESFITEE VDESSSPQQG TRAASIENVL QDSSPEHCGR GPPADIYLPA
   541  LGPDSCSVGI DE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MGRN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
63 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 63 nTPM
  • liver: 51 nTPM
  • skeletal muscle: 50 nTPM
  • cerebral cortex: 49 nTPM
  • spleen: 36 nTPM
  • hippocampal formation: 36 nTPM

Single-cell type

  • neutrophils: 293 nCPM
  • müller glia: 140 nCPM
  • neutrophil progenitors: 115 nCPM
  • paneth cells: 101 nCPM
  • myonuclei: 97 nCPM
  • enterocytes: 96 nCPM

Immune cell

  • neutrophil: 16 nTPM
  • basophil: 5.5 nTPM
  • plasmacytoid DC: 4.1 nTPM
  • intermediate monocyte: 3.9 nTPM
  • eosinophil: 3.8 nTPM
  • total PBMC: 3.7 nTPM

Brain region

  • hippocampal formation: 104 nTPM
  • white matter: 96 nTPM
  • cerebral cortex: 93 nTPM
  • amygdala: 88 nTPM
  • basal ganglia: 81 nTPM
  • medulla oblongata: 80 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.1
gnomAD missense Z
-1.55
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MGRN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MGRN1 as an antibody target. Whether an autoantibody or antibody against MGRN1 could matter depends on whether native MGRN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MGRN1 is annotated at the cell surface, where native MGRN1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MGRN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MGRN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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