Seroatlas · Human Serome Atlas

VPS37D

Vacuolar protein sorting-associated protein 37D

Also known as: MGC35352, VP37D_HUMAN, WBSCR24

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86XT2
Gene: VPS37D
Ensembl: ENSG00000176428
Chromosome: 7
Canonical length: 251 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be involved in protein targeting to membrane; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Located in extracellular exosome. Part of ESCRT I complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

251 residues, UniProt reviewed canonical sequence.

>Q86XT2|VPS37D
     1  MYRARAARAG PEPGSPGRFG ILSTGQLRDL LQDEPKLDRI VRLSRKFQGL QLEREACLAS
    61  NYALAKENLA LRPRLEMGRA ALAIKYQELR EVAENCADKL QRLEESMHRW SPHCALGWLQ
   121  AELEEAEQEA EEQMEQLLLG EQSLEAFLPA FQRGRALAHL RRTQAEKLQE LLRRRERSAQ
   181  PAPTSAADPP KSFPAAAVLP TGAARGPPAV PRSLPPLDSR PVPPLKGSPG CPLGPAPLLS
   241  PRPSQPEPPH R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VPS37D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

kidney: 13 nTPM
cerebral cortex: 11 nTPM
liver: 10 nTPM
basal ganglia: 9.9 nTPM
cerebellum: 9.2 nTPM
hypothalamus: 9.2 nTPM

Single-cell type

epididymal clear cells: 31 nCPM
epididymal principal cells: 19 nCPM
epididymal efferent duct absorptive cells: 15 nCPM
undifferentiated spermatogonia: 13 nCPM
pancreatic duct cells: 10 nCPM
retinal bipolar cells: 9.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 13 nTPM
basal ganglia: 13 nTPM
hypothalamus: 13 nTPM
amygdala: 12 nTPM
pons: 12 nTPM
cerebellum: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.92
gnomAD missense Z: 0.88
DepMap mean gene effect: -0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VPS37D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VPS37D as an antibody target. Whether an autoantibody or antibody against VPS37D could matter depends on whether native VPS37D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VPS37D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VPS37D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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