Seroatlas · Human Serome Atlas

MVB12A

Multivesicular body subunit 12A

Also known as: FAM125A, FLJ32495, MB12A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96EY5
Gene: MVB12A
Ensembl: ENSG00000141971
Chromosome: 19
Canonical length: 273 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables lipid binding activity and ubiquitin binding activity. Involved in regulation of epidermal growth factor receptor signaling pathway. Located in several cellular components, including centrosome; cytosol; and vesicle. Part of ESCRT I complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

273 residues, UniProt reviewed canonical sequence.

>Q96EY5|MVB12A
     1  MDPVPGTDSA PLAGLAWSSA SAPPPRGFSA ISCTVEGAPA SFGKSFAQKS GYFLCLSSLG
    61  SLENPQENVV ADIQIVVDKS PLPLGFSPVC DPMDSKASVS KKKRMCVKLL PLGATDTAVF
   121  DVRLSGKTKT VPGYLRIGDM GGFAIWCKKA KAPRPVPKPR GLSRDMQGLS LDAASQPSKG
   181  GLLERTASRL GSRASTLRRN DSIYEASSLY GISAMDGVPF TLHPRFEGKS CSPLAFSAFG
   241  DLTIKSLADI EEEYNYGFVV EKTAAARLPP SVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MVB12A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

ovary: 48 nTPM
esophagus: 46 nTPM
adrenal gland: 44 nTPM
skin: 37 nTPM
kidney: 37 nTPM
thyroid gland: 36 nTPM

Single-cell type

esophageal apical cells: 242 nCPM
esophageal suprabasal cells: 166 nCPM
extravillous trophoblasts: 129 nCPM
decidual stromal cells: 108 nCPM
esophageal basal cells: 108 nCPM
hofbauer cells: 100 nCPM

Immune cell

intermediate monocyte: 67 nTPM
classical monocyte: 62 nTPM
myeloid DC: 61 nTPM
basophil: 58 nTPM
T-reg: 57 nTPM
non-classical monocyte: 54 nTPM

Brain region

medulla oblongata: 21 nTPM
white matter: 20 nTPM
spinal cord: 17 nTPM
choroid plexus: 16 nTPM
thalamus: 16 nTPM
cerebellum: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0
gnomAD missense Z: -0.2
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

UMA domain
MABP domain
MABP domain
Multivesicular body subunit 12A

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MVB12A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MVB12A as an antibody target. Whether an autoantibody or antibody against MVB12A could matter depends on whether native MVB12A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MVB12A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MVB12A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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