Seroatlas · Human Serome Atlas

SEC23A

Protein transport protein Sec23A

Also known as: SC23A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15436
Gene: SEC23A
Ensembl: ENSG00000100934
Chromosome: 14
Canonical length: 765 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

765 residues, UniProt reviewed canonical sequence.

>Q15436|SEC23A
     1  MTTYLEFIQQ NEERDGVRFS WNVWPSSRLE ATRMVVPVAA LFTPLKERPD LPPIQYEPVL
    61  CSRTTCRAVL NPLCQVDYRA KLWACNFCYQ RNQFPPSYAG ISELNQPAEL LPQFSSIEYV
   121  VLRGPQMPLI FLYVVDTCME DEDLQALKES MQMSLSLLPP TALVGLITFG RMVQVHELGC
   181  EGISKSYVFR GTKDLSAKQL QEMLGLSKVP LTQATRGPQV QQPPPSNRFL QPVQKIDMNL
   241  TDLLGELQRD PWPVPQGKRP LRSSGVALSI AVGLLECTFP NTGARIMMFI GGPATQGPGM
   301  VVGDELKTPI RSWHDIDKDN AKYVKKGTKH FEALANRAAT TGHVIDIYAC ALDQTGLLEM
   361  KCCPNLTGGY MVMGDSFNTS LFKQTFQRVF TKDMHGQFKM GFGGTLEIKT SREIKISGAI
   421  GPCVSLNSKG PCVSENEIGT GGTCQWKICG LSPTTTLAIY FEVVNQHNAP IPQGGRGAIQ
   481  FVTQYQHSSG QRRIRVTTIA RNWADAQTQI QNIAASFDQE AAAILMARLA IYRAETEEGP
   541  DVLRWLDRQL IRLCQKFGEY HKDDPSSFRF SETFSLYPQF MFHLRRSSFL QVFNNSPDES
   601  SYYRHHFMRQ DLTQSLIMIQ PILYAYSFSG PPEPVLLDSS SILADRILLM DTFFQILIYH
   661  GETIAQWRKS GYQDMPEYEN FRHLLQAPVD DAQEILHSRF PMPRYIDTEH GGSQARFLLS
   721  KVNPSQTHNN MYAWGQESGA PILTDDVSLQ VFMDHLKKLA VSSAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEC23A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 84 nTPM

Expression across tissuesHPA

Tissue

smooth muscle: 84 nTPM
liver: 76 nTPM
tongue: 55 nTPM
duodenum: 54 nTPM
blood vessel: 53 nTPM
skeletal muscle: 51 nTPM

Single-cell type

enterocytes: 189 nCPM
hepatocytes: 179 nCPM
lactotrophs: 178 nCPM
somatotrophs: 164 nCPM
gonadotrophs: 144 nCPM
neutrophil progenitors: 138 nCPM

Immune cell

basophil: 70 nTPM
NK-cell: 42 nTPM
eosinophil: 39 nTPM
MAIT T-cell: 38 nTPM
T-reg: 38 nTPM
naive CD4 T-cell: 35 nTPM

Brain region

choroid plexus: 101 nTPM
hypothalamus: 74 nTPM
cerebellum: 72 nTPM
cerebral cortex: 69 nTPM
pons: 68 nTPM
midbrain: 65 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SEC23A.

Disease | AllUniProt

Conditions SEC23A is implicated in, by any mechanism.

Craniolenticulosutural dysplasia (CLSD) MIM:607812

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 264 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Craniolenticulosutural dysplasia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0
gnomAD missense Z: 1.79
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEC23A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEC23A as an antibody target. Whether an autoantibody or antibody against SEC23A could matter depends on whether native SEC23A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEC23A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEC23A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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