IL1A

Protein identityUniProt · HPA

UniProt accession

P01583

Gene

IL1A

Ensembl

ENSG00000115008

Chromosome

2

Canonical length

271 aa

Protein class

Cancer-related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Transporters

Subcellular location

Cytosol

Secretome location

Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>P01583|IL1A
     1  MAKVPDMFED LKNCYSENEE DSSSIDHLSL NQKSFYHVSY GPLHEGCMDQ SVSLSISETS
    61  KTSKLTFKES MVVVATNGKV LKKRRLSLSQ SITDDDLEAI ANDSEEEIIK PRSAPFSFLS
   121  NVKYNFMRII KYEFILNDAL NQSIIRANDQ YLTAAALHNL DEAVKFDMGA YKSSKDDAKI
   181  TVILRISKTQ LYVTAQDEDQ PVLLKEMPEI PKTITGSETN LLFFWETHGT KNYFTSVAHP
   241  NLFIATKQDY WVCLAGGPPS ITDFQILENQ A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.46

Highest tissue expression

24 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IL1A.

Disease | AutoantibodyPubMed

Conditions in which antibodies against IL1A are reported. Each links to that disease's full target list.

• Arthritis, Rheumatoid 6
• Urticaria 4
• Arthritis 3
• Kidney Failure, Chronic 3

ReferencesPubMed · IEDB

Publications for IL1A from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.31

gnomAD pLI

0

gnomAD missense Z

0.54

DepMap mean gene effect

0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• cellular response to heat
• cellular response to lipopolysaccharide
• connective tissue replacement involved in inflammatory response wound healing
• cytokine-mediated signaling pathway
• ectopic germ cell programmed cell death
• extrinsic apoptotic signaling pathway in absence of ligand
• fever generation
• immune response
• inflammatory response
• intracellular sodium ion homeostasis
• negative regulation of cell population proliferation
• negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
• positive regulation of angiogenesis
• positive regulation of canonical NF-kappaB signal transduction
• positive regulation of cell division
• positive regulation of cytokine production
• positive regulation of gene expression
• positive regulation of immature T cell proliferation in thymus
• positive regulation of interleukin-2 production
• positive regulation of interleukin-6 production
• positive regulation of mitotic nuclear division
• positive regulation of protein secretion
• positive regulation of transcription by RNA polymerase II
• positive regulation of tumor necrosis factor production
• positive regulation of vascular endothelial growth factor production
• regulation of ERK1 and ERK2 cascade
• response to copper ion

Molecular functions

• copper ion binding
• cytokine activity
• interleukin-1 receptor binding

Cellular components

• cytosol
• extracellular region
• extracellular space
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Interleukin-1 family
• Interleukin-1 propeptide
• Cytokine IL1/FGF
• Interleukin-1 conserved site
• Interleukin-1 / 18
• Interleukin-1 propeptide
• Interleukin-1 alpha

KeywordsUniProt

• Acetylation
• Cytokine
• Cytoplasm
• Glycoprotein
• Inflammatory response
• Lipoprotein
• Mitogen
• Myristate
• Nucleus
• Phosphoprotein
• Pyrogen
• Secreted

InteractionsUniProt · HPA

Protein binding partners of IL1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IL1R1
• S100A13
• TMED10
• HAX1