Seroatlas · Human Serome Atlas

TMED9

Transmembrane emp24 domain-containing protein 9

Also known as: HSGP25L2G, p24a2, p24alpha2, TMED9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BVK6
Gene: TMED9
Ensembl: ENSG00000184840
Chromosome: 5
Canonical length: 235 aa
Protein class: Predicted membrane proteins, Transporters
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene is a member of a family of genes encoding transport proteins located in the endoplasmic reticulum and the Golgi. A similar gene in mouse is the target of microRNA miR-296, which is part of an imprinted cluster. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>Q9BVK6|TMED9
     1  MAVELGVLLV RPRPGTGLGR VMRTLLLVLW LATRGSALYF HIGETEKKCF IEEIPDETMV
    61  IGNYRTQLYD KQREEYQPAT PGLGMFVEVK DPEDKVILAR QYGSEGRFTF TSHTPGEHQI
   121  CLHSNSTKFS LFAGGMLRVH LDIQVGEHAN DYAEIAAKDK LSELQLRVRQ LVEQVEQIQK
   181  EQNYQRWREE RFRQTSESTN QRVLWWSILQ TLILVAIGVW QMRHLKSFFE AKKLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMED9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 96 nTPM

Expression across tissuesHPA

Tissue

pancreas: 96 nTPM
choroid plexus: 90 nTPM
liver: 89 nTPM
salivary gland: 73 nTPM
epididymis: 62 nTPM
placenta: 56 nTPM

Single-cell type

extravillous trophoblasts: 1,278 nCPM
syncytiotrophoblasts: 1,002 nCPM
migrating cytotrophoblasts: 637 nCPM
esophageal apical cells: 625 nCPM
cytotrophoblasts: 609 nCPM
epididymal principal cells: 503 nCPM

Immune cell

plasmacytoid DC: 202 nTPM
total PBMC: 132 nTPM
classical monocyte: 98 nTPM
intermediate monocyte: 95 nTPM
myeloid DC: 92 nTPM
non-classical monocyte: 89 nTPM

Brain region

choroid plexus: 42 nTPM
thalamus: 22 nTPM
medulla oblongata: 22 nTPM
midbrain: 19 nTPM
spinal cord: 19 nTPM
pons: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0.01
gnomAD missense Z: 0.93
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

syntaxin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMED9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMED9 as an antibody target. Whether an autoantibody or antibody against TMED9 could matter depends on whether native TMED9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMED9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMED9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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