Seroatlas · Human Serome Atlas

SEC24C

Protein transport protein Sec24C

Also known as: KIAA0079, SC24C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P53992
Gene: SEC24C
Ensembl: ENSG00000176986
Chromosome: 10
Canonical length: 1094 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1094 residues, UniProt reviewed canonical sequence.

>P53992|SEC24C
     1  MNVNQSVPPV PPFGQPQPIY PGYHQSSYGG QSGSTAPAIP YGAYNGPVPG YQQTPPQGMS
    61  RAPPSSGAPP ASTAQAPCGQ AAYGQFGQGD VQNGPSSTVQ MQRLPGSQPF GSPLAPVGNQ
   121  PPVLQPYGPP PTSAQVATQL SGMQISGAVA PAPPSSGLGF GPPTSLASAS GSFPNSGLYG
   181  SYPQGQAPPL SQAQGHPGIQ TPQRSAPSQA SSFTPPASGG PRLPSMTGPL LPGQSFGGPS
   241  VSQPNHVSSP PQALPPGTQM TGPLGPLPPM HSPQQPGYQP QQNGSFGPAR GPQSNYGGPY
   301  PAAPTFGSQP GPPQPLPPKR LDPDAIPSPI QVIEDDRNNR GTEPFVTGVR GQVPPLVTTN
   361  FLVKDQGNAS PRYIRCTSYN IPCTSDMAKQ AQVPLAAVIK PLARLPPEEA SPYVVDHGES
   421  GPLRCNRCKA YMCPFMQFIE GGRRFQCCFC SCINDVPPQY FQHLDHTGKR VDAYDRPELS
   481  LGSYEFLATV DYCKNNKFPS PPAFIFMIDV SYNAIRTGLV RLLCEELKSL LDFLPREGGA
   541  EESAIRVGFV TYNKVLHFYN VKSSLAQPQM MVVSDVADMF VPLLDGFLVN VNESRAVITS
   601  LLDQIPEMFA DTRETETVFV PVIQAGMEAL KAAECAGKLF LFHTSLPIAE APGKLKNRDD
   661  RKLINTDKEK TLFQPQTGAY QTLAKECVAQ GCCVDLFLFP NQYVDVATLS VVPQLTGGSV
   721  YKYASFQVEN DQERFLSDLR RDVQKVVGFD AVMRVRTSTG IRAVDFFGAF YMSNTTDVEL
   781  AGLDGDKTVT VEFKHDDRLN EESGALLQCA LLYTSCAGQR RLRIHNLALN CCTQLADLYR
   841  NCETDTLINY MAKFAYRGVL NSPVKAVRDT LITQCAQILA CYRKNCASPS SAGQLILPEC
   901  MKLLPVYLNC VLKSDVLQPG AEVTTDDRAY VRQLVTSMDV TETNVFFYPR LLPLTKSPVE
   961  STTEPPAVRA SEERLSNGDI YLLENGLNLF LWVGASVQQG VVQSLFSVSS FSQITSGLSV
  1021  LPVLDNPLSK KVRGLIDSLR AQRSRYMKLT VVKQEDKMEM LFKHFLVEDK SLSGGASYVD
  1081  FLCHMHKEIR QLLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEC24C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

esophagus: 66 nTPM
parathyroid gland: 48 nTPM
skeletal muscle: 47 nTPM
pituitary gland: 43 nTPM
liver: 43 nTPM
tonsil: 41 nTPM

Single-cell type

esophageal apical cells: 194 nCPM
syncytiotrophoblasts: 61 nCPM
tuft cells: 58 nCPM
esophageal suprabasal cells: 50 nCPM
neutrophil progenitors: 42 nCPM
neutrophils: 41 nCPM

Immune cell

MAIT T-cell: 36 nTPM
basophil: 28 nTPM
gdT-cell: 27 nTPM
total PBMC: 23 nTPM
NK-cell: 23 nTPM
memory CD8 T-cell: 22 nTPM

Brain region

cerebral cortex: 62 nTPM
cerebellum: 47 nTPM
thalamus: 47 nTPM
white matter: 46 nTPM
medulla oblongata: 45 nTPM
pons: 44 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SEC24C.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 197 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Developmental and epileptic encephalopathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 1.5
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEC24C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEC24C as an antibody target. Whether an autoantibody or antibody against SEC24C could matter depends on whether native SEC24C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEC24C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEC24C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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