Seroatlas · Human Serome Atlas

MPPE1

Metallophosphoesterase 1

Also known as: Cdc1, MPPE1_HUMAN, PGAP5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q53F39
Gene
MPPE1
Ensembl
ENSG00000154889
Chromosome
18
Canonical length
396 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to enable GPI anchor binding activity; GPI-mannose ethanolamine phosphate phosphodiesterase activity; and manganese ion binding activity. Involved in GPI anchor biosynthetic process. Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

396 residues, UniProt reviewed canonical sequence.

>Q53F39|MPPE1
     1  MAMIELGFGR QNFHPLKRKS SLLLKLIAVV FAVLLFCEFL IYYLAIFQCN WPEVKTTASD
    61  GEQTTREPVL KAMFLADTHL LGEFLGHWLD KLRREWQMER AFQTALWLLQ PEVVFILGDI
   121  FDEGKWSTPE AWADDVERFQ KMFRHPSHVQ LKVVAGNHDI GFHYEMNTYK VERFEKVFSS
   181  ERLFSWKGIN FVMVNSVALN GDGCGICSET EAELIEVSHR LNCSREARGS SRCGPGPLLP
   241  TSAPVLLQHY PLYRRSDANC SGEDAAPAEE RDIPFKENYD VLSREASQKL LWWLQPRLVL
   301  SGHTHSACEV HHGGRVPELS VPSFSWRNRN NPSFIMGSIT PTDYTLSKCY LPREDVVLII
   361  YCGVVGFLVV LTLTHFGLLA SPFLSGLNLL GKRKTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MPPE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 44 nTPM
  • pancreas: 30 nTPM
  • skin: 27 nTPM
  • kidney: 27 nTPM
  • bone marrow: 27 nTPM
  • lung: 24 nTPM

Single-cell type

  • neutrophils: 114 nCPM
  • microglia: 85 nCPM
  • alveolar cells type 1: 74 nCPM
  • myonuclei: 74 nCPM
  • foveolar cells: 67 nCPM
  • neutrophil progenitors: 67 nCPM

Immune cell

  • neutrophil: 297 nTPM
  • eosinophil: 102 nTPM
  • classical monocyte: 43 nTPM
  • myeloid DC: 38 nTPM
  • intermediate monocyte: 35 nTPM
  • total PBMC: 32 nTPM

Brain region

  • medulla oblongata: 27 nTPM
  • pons: 27 nTPM
  • white matter: 26 nTPM
  • thalamus: 26 nTPM
  • midbrain: 26 nTPM
  • hypothalamus: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.21
gnomAD pLI
0
gnomAD missense Z
0.35
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MPPE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MPPE1 as an antibody target. Whether an autoantibody or antibody against MPPE1 could matter depends on whether native MPPE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MPPE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MPPE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MPPE1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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