Seroatlas · Human Serome Atlas

TMED1

Transmembrane emp24 domain-containing protein 1

Also known as: Il1rl1l, IL1RL1LG, MGC1270, p24g1, p24gamma1, ST2L, TMED1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13445
Gene
TMED1
Ensembl
ENSG00000099203
Chromosome
19
Canonical length
227 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the vesicular trafficking of proteins. The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may play a role in innate immunity. This protein lacks any similarity to other interleukin 1 ligands. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

227 residues, UniProt reviewed canonical sequence.

>Q13445|TMED1
     1  MMAAGAALAL ALWLLMPPVE VGGAGPPPIQ DGEFTFLLPA GRKQCFYQSA PANASLETEY
    61  QVIGGAGLDV DFTLESPQGV LLVSESRKAD GVHTVEPTEA GDYKLCFDNS FSTISEKLVF
   121  FELIFDSLQD DEEVEGWAEA VEPEEMLDVK MEDIKESIET MRTRLERSIQ MLTLLRAFEA
   181  RDRNLQEGNL ERVNFWSAVN VAVLLLVAVL QVCTLKRFFQ DKRPVPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMED1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
61 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 61 nTPM
  • liver: 52 nTPM
  • choroid plexus: 47 nTPM
  • kidney: 38 nTPM
  • heart muscle: 38 nTPM
  • pituitary gland: 35 nTPM

Single-cell type

  • syncytiotrophoblasts: 174 nCPM
  • cytotrophoblasts: 133 nCPM
  • extravillous trophoblasts: 126 nCPM
  • migrating cytotrophoblasts: 116 nCPM
  • decidual stromal cells: 85 nCPM
  • fallopian tube ciliated cells: 74 nCPM

Immune cell

  • NK-cell: 123 nTPM
  • non-classical monocyte: 104 nTPM
  • classical monocyte: 95 nTPM
  • intermediate monocyte: 94 nTPM
  • myeloid DC: 81 nTPM
  • total PBMC: 66 nTPM

Brain region

  • choroid plexus: 36 nTPM
  • white matter: 20 nTPM
  • hypothalamus: 19 nTPM
  • medulla oblongata: 19 nTPM
  • cerebellum: 17 nTPM
  • spinal cord: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.7
gnomAD pLI
0
gnomAD missense Z
0.52
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMED1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMED1 as an antibody target. Whether an autoantibody or antibody against TMED1 could matter depends on whether native TMED1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMED1 is annotated at the cell surface, where native TMED1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMED1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMED1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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