Seroatlas · Human Serome Atlas

IL36A

Interleukin-36 alpha

Also known as: FIL1, FIL1E, IL-1F6, IL1(EPSILON), IL1F6, IL36A_HUMAN, MGC129552, MGC129553

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UHA7
Gene: IL36A
Ensembl: ENSG00000136694
Chromosome: 2
Canonical length: 158 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

158 residues, UniProt reviewed canonical sequence.

>Q9UHA7|IL36A
     1  MEKALKIDTP QQGSIQDINH RVWVLQDQTL IAVPRKDRMS PVTIALISCR HVETLEKDRG
    61  NPIYLGLNGL NLCLMCAKVG DQPTLQLKEK DIMDLYNQPE PVKSFLFYHS QSGRNSTFES
   121  VAFPGWFIAV SSEGGCPLIL TQELGKANTT DFGLTMLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL36A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 386 nTPM

Expression across tissuesHPA

Tissue

esophagus: 386 nTPM
tonsil: 108 nTPM
cervix: 29 nTPM
vagina: 16 nTPM
salivary gland: 16 nTPM
thymus: 1.8 nTPM

Single-cell type

esophageal apical cells: 215 nCPM
suprabasal keratinocytes: 9.5 nCPM
esophageal suprabasal cells: 1.5 nCPM
esophageal basal cells: 0.8 nCPM
lymphatic endothelial cells: 0.2 nCPM
basal keratinocytes: 0.1 nCPM

Immune cell

naive CD4 T-cell: 0.5 nTPM
naive CD8 T-cell: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM
T-reg: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0.03
gnomAD missense Z: -0.29
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IL36A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TMED10

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL36A as an antibody target. Whether an autoantibody or antibody against IL36A could matter depends on whether native IL36A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL36A is annotated as secreted, so native IL36A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IL36A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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