Seroatlas · Human Serome Atlas

COPG2

Coatomer subunit gamma-2

Also known as: 2-COP, COPG2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBF2
Gene
COPG2
Ensembl
ENSG00000158623
Chromosome
7
Canonical length
871 aa
Protein class
Metabolic proteins, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable structural molecule activity. Involved in intra-Golgi vesicle-mediated transport. Part of COPI vesicle coat. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

871 residues, UniProt reviewed canonical sequence.

>Q9UBF2|COPG2
     1  MIKKFDKKDE ESGSGSNPFQ HLEKSAVLQE ARIFNETPIN PRRCLHILTK ILYLLNQGEH
    61  FGTTEATEAF FAMTRLFQSN DQTLRRMCYL TIKEMATISE DVIIVTSSLT KDMTGKEDVY
   121  RGPAIRALCR ITDGTMLQAI ERYMKQAIVD KVSSVSSSAL VSSLHMMKIS YDVVKRWINE
   181  AQEAASSDNI MVQYHALGVL YHLRKNDRLA VSKMLNKFTK SGLKSQFAYC MLIRIASRLL
   241  KETEDGHESP LFDFIESCLR NKHEMVIYEA ASAIIHLPNC TARELAPAVS VLQLFCSSPK
   301  PALRYAAVRT LNKVAMKHPS AVTACNLDLE NLITDSNRSI ATLAITTLLK TGSESSVDRL
   361  MKQISSFVSE ISDEFKVVVV QAISALCQKY PRKHSVMMTF LSNMLRDDGG FEYKRAIVDC
   421  IISIVEENPE SKEAGLAHLC EFIEDCEHTV LATKILHLLG KEGPRTPVPS KYIRFIFNRV
   481  VLENEAVRAA AVSALAKFGA QNESLLPSIL VLLQRCMMDT DDEVRDRATF YLNVLQQRQM
   541  ALNATYIFNG LTVSVPGMEK ALHQYTLEPS EKPFDMKSIP LAMAPVFEQK AEITLVATKP
   601  EKLAPSRQDI FQEQLAAIPE FLNIGPLFKS SEPVQLTEAE TEYFVRCIKH MFTNHIVFQF
   661  DCTNTLNDQL LEKVTVQMEP SDSYEVLSCI PAPSLPYNQP GICYTLVRLP DDDPTAVAGS
   721  FSCTMKFTVR DCDPNTGVPD EDGYDDEYVL EDLEVTVSDH IQKVLKPNFA AAWEEVGDTF
   781  EKEETFALSS TKTLEEAVNN IITFLGMQPC ERSDKVPENK NSHSLYLAGI FRGGYDLLVR
   841  SRLALADGVT MQVTVRSKER TPVDVILASV G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COPG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 28 nTPM
  • retina: 26 nTPM
  • parathyroid gland: 24 nTPM
  • testis: 23 nTPM
  • adrenal gland: 20 nTPM
  • skin: 20 nTPM

Single-cell type

  • adipocytes: 860 nCPM
  • epicardial cells: 277 nCPM
  • thyrotrophs: 195 nCPM
  • corticotrophs: 131 nCPM
  • lactotrophs: 129 nCPM
  • undifferentiated spermatogonia: 114 nCPM

Immune cell

  • eosinophil: 2.6 nTPM
  • non-classical monocyte: 2 nTPM
  • myeloid DC: 1.8 nTPM
  • memory B-cell: 1.6 nTPM
  • classical monocyte: 1.5 nTPM
  • intermediate monocyte: 1.4 nTPM

Brain region

  • hypothalamus: 89 nTPM
  • basal ganglia: 55 nTPM
  • midbrain: 55 nTPM
  • cerebral cortex: 52 nTPM
  • pons: 44 nTPM
  • medulla oblongata: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0.01
gnomAD missense Z
0.98

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COPG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COPG2 as an antibody target. Whether an autoantibody or antibody against COPG2 could matter depends on whether native COPG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COPG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COPG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COPG2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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