Seroatlas · Human Serome Atlas

STRBP

Spermatid perinuclear RNA-binding protein

Also known as: FLJ11307, ILF3L, SPNR, STRBP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96SI9
Gene: STRBP
Ensembl: ENSG00000165209
Chromosome: 9
Canonical length: 672 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in cell differentiation and spermatogenesis. Predicted to act upstream of or within cell motility; mechanosensory behavior; and spermatid development. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

672 residues, UniProt reviewed canonical sequence.

>Q96SI9|STRBP
     1  MRSIRSFAND DRHVMVKHST IYPSPEELEA VQNMVSTVEC ALKHVSDWLD ETNKGTKTEG
    61  ETEVKKDEAG ENYSKDQGGR TLCGVMRIGL VAKGLLIKDD MDLELVLMCK DKPTETLLNT
   121  VKDNLPIQIQ KLTEEKYQVE QCVNEASIII RNTKEPTLTL KVILTSPLIR DELEKKDGEN
   181  VSMKDPPDLL DRQKCLNALA SLRHAKWFQA RANGLKSCVI VLRILRDLCN RVPTWAPLKG
   241  WPLELICEKS IGTCNRPLGA GEALRRVMEC LASGILLPGG PGLHDPCERD PTDALSYMTI
   301  QQKEDITHSA QHALRLSAFG QIYKVLEMDP LPSSKPFQKY SWSVTDKEGA GSSALKRPFE
   361  DGLGDDKDPN KKMKRNLRKI LDSKAIDLMN ALMRLNQIRP GLQYKLLSQS GPVHAPVFTM
   421  SVDVDGTTYE ASGPSKKTAK LHVAVKVLQA MGYPTGFDAD IECMSSDEKS DNESKNETVS
   481  SNSSNNTGNS TTETSSTLEV RTQGPILTAS GKNPVMELNE KRRGLKYELI SETGGSHDKR
   541  FVMEVEVDGQ KFRGAGPNKK VAKASAALAA LEKLFSGPNA ANNKKKKIIP QAKGVVNTAV
   601  SAAVQAVRGR GRGTLTRGAF VGATAAPGYI APGYGTPYGY STAAPAYGLP KRMVLLPVMK
   661  FPTYPVPHYS FF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STRBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 35 nTPM
testis: 35 nTPM
tonsil: 33 nTPM
lymph node: 28 nTPM
thymus: 22 nTPM
retina: 20 nTPM

Single-cell type

pituitary stem cells: 706 nCPM
ependymal cells: 648 nCPM
respiratory ciliated cells: 517 nCPM
b-cells: 462 nCPM
pdcs: 416 nCPM
endometrial ciliated cells: 414 nCPM

Immune cell

memory B-cell: 8.1 nTPM
naive B-cell: 6.3 nTPM
plasmacytoid DC: 5 nTPM
basophil: 3.7 nTPM
NK-cell: 1.9 nTPM
naive CD4 T-cell: 1.6 nTPM

Brain region

cerebral cortex: 59 nTPM
choroid plexus: 41 nTPM
cerebellum: 40 nTPM
thalamus: 40 nTPM
white matter: 40 nTPM
midbrain: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 3.48
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

DZF domain
Double-stranded RNA-binding domain
Nucleotidyltransferase superfamily
DZF domain, N-terminal
DZF domain, C-terminal
Double-stranded RNA binding motif
DZF N-terminal domain
DZF C-terminal domain
STRBP, first double-stranded RNA binding domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STRBP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STRBP as an antibody target. Whether an autoantibody or antibody against STRBP could matter depends on whether native STRBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STRBP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STRBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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