Seroatlas · Human Serome Atlas

NCAPH

Condensin complex subunit 2

Also known as: BRRN1, CAP-H, CND2_HUMAN, hCAP-H

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15003
Gene: NCAPH
Ensembl: ENSG00000121152
Chromosome: 2
Canonical length: 741 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization. Alternatively spliced transcript variants encoding different proteins have been described. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

741 residues, UniProt reviewed canonical sequence.

>Q15003|NCAPH
     1  MGPPGPALPA TMNNSSSETR GHPHSASSPS ERVFPMPLPR KAPLNIPGTP VLEDFPQNDD
    61  EKERLQRRRS RVFDLQFSTD SPRLLASPSS RSIDISATIP KFTNTQITEH YSTCIKLSTE
   121  NKITTKNAFG LHLIDFMSEI LKQKDTEPTN FKVAAGTLDA STKIYAVRVD AVHADVYRVL
   181  GGLGKDAPSL EEVEGHVADG SATEMGTTKK AVKPKKKHLH RTIEQNINNL NVSEADRKCE
   241  IDPMFQKTAA SFDECSTAGV FLSTLHCQDY RSELLFPSDV QTLSTGEPLE LPELGCVEMT
   301  DLKAPLQQCA EDRQICPSLA GFQFTQWDSE THNESVSALV DKFKKNDQVF DINAEVDESD
   361  CGDFPDGSLG DDFDANDEPD HTAVGDHEEF RSWKEPCQVQ SCQEEMISLG DGDIRTMCPL
   421  LSMKPGEYSY FSPRTMSMWA GPDHWRFRPR RKQDAPSQSE NKKKSTKKDF EIDFEDDIDF
   481  DVYFRKTKAA TILTKSTLEN QNWRATTLPT DFNYNVDTLV QLHLKPGTRL LKMAQGHRVE
   541  TEHYEEIEDY DYNNPNDTSN FCPGLQAADS DDEDLDDLFV GPVGNSDLSP YPCHPPKTAQ
   601  QNGDTPEAQG LDITTYGESN LVAEPQKVNK IEIHYAKTAK KMDMKKLKQS MWSLLTALSG
   661  KEADAEANHR EAGKEAALAE VADEKMLSGL TKDLQRSLPP VMAQNLSIPL AFACLLHLAN
   721  EKNLKLEGTE DLSDVLVRQG D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCAPH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

thymus: 35 nTPM
bone marrow: 33 nTPM
testis: 33 nTPM
tonsil: 21 nTPM
lymph node: 19 nTPM
appendix: 9.4 nTPM

Single-cell type

late primary spermatocytes: 103 nCPM
erythrocyte progenitors: 97 nCPM
monocyte progenitors: 90 nCPM
oocytes: 74 nCPM
early primary spermatocytes: 72 nCPM
megakaryocyte progenitors: 60 nCPM

Immune cell

T-reg: 6.2 nTPM
basophil: 3.7 nTPM
memory CD4 T-cell: 1.2 nTPM
memory CD8 T-cell: 1 nTPM
intermediate monocyte: 0.9 nTPM
memory B-cell: 0.9 nTPM

Brain region

cerebellum: 5.7 nTPM
cerebral cortex: 5.2 nTPM
basal ganglia: 4.5 nTPM
pons: 4.5 nTPM
choroid plexus: 4.4 nTPM
white matter: 4.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NCAPH.

Disease | AllUniProt

Conditions NCAPH is implicated in, by any mechanism.

Microcephaly 23, primary, autosomal recessive (MCPH23) MIM:617985

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 150 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Microcephaly 23, primary, autosomal recessive

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0
gnomAD missense Z: 1.09
DepMap mean gene effect: -1.06
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

chromatin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Condensin complex subunit 2/barren
Condensin complex subunit 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NCAPH in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NCAPH as an antibody target. Whether an autoantibody or antibody against NCAPH could matter depends on whether native NCAPH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NCAPH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NCAPH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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