Seroatlas · Human Serome Atlas

GEMIN7

Gem-associated protein 7

Also known as: FLJ13956, GEMI7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H840
Gene: GEMIN7
Ensembl: ENSG00000142252
Chromosome: 19
Canonical length: 131 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear """"""""""""""""""""""""""""""""gems"""""""""""""""""""""""""""""""" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

131 residues, UniProt reviewed canonical sequence.

>Q9H840|GEMIN7
     1  MQTPVNIPVP VLRLPRGPDG FSRGFAPDGR RAPLRPEVPE IQECPIAQES LESQEQRARA
    61  ALRERYLRSL LAMVGHQVSF TLHEGVRVAA HFGATDLDVA NFYVSQLQTP IGVQAEALLR
   121  CSDIISYTFK P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GEMIN7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

spleen: 36 nTPM
skeletal muscle: 33 nTPM
liver: 31 nTPM
esophagus: 29 nTPM
lymph node: 25 nTPM
stomach: 23 nTPM

Single-cell type

myonuclei: 1.4 nCPM
cardiomyocytes: 0.9 nCPM
mucous neck cells: 0.8 nCPM
corticotrophs: 0.7 nCPM
endometrial secretory cells: 0.6 nCPM
salivary myoepithelial cells: 0.6 nCPM

Immune cell

NK-cell: 75 nTPM
gdT-cell: 71 nTPM
MAIT T-cell: 68 nTPM
memory B-cell: 68 nTPM
memory CD8 T-cell: 65 nTPM
naive B-cell: 58 nTPM

Brain region

choroid plexus: 18 nTPM
thalamus: 16 nTPM
midbrain: 16 nTPM
white matter: 15 nTPM
cerebellum: 15 nTPM
cerebral cortex: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0.65
gnomAD missense Z: 0.35
DepMap mean gene effect: -0.67
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

SUZ-C domain
Sm domain
SMN complex, gem-associated protein 7
Gem-associated protein 7 (Gemin7)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GEMIN7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GEMIN7 as an antibody target. Whether an autoantibody or antibody against GEMIN7 could matter depends on whether native GEMIN7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GEMIN7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GEMIN7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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