Seroatlas · Human Serome Atlas

GEMIN2

Gem-associated protein 2

Also known as: GEMI2_HUMAN, SIP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14893
Gene
GEMIN2
Ensembl
ENSG00000092208
Chromosome
14
Canonical length
280 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Nuclear bodies

OverviewNCBI Gene

This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

280 residues, UniProt reviewed canonical sequence.

>O14893|GEMIN2
     1  MRRAELAGLK TMAWVPAESA VEELMPRLLP VEPCDLTEGF DPSVPPRTPQ EYLRRVQIEA
    61  AQCPDVVVAQ IDPKKLKRKQ SVNISLSGCQ PAPEGYSPTL QWQQQQVAQF STVRQNVNKH
   121  RSHWKSQQLD SNVTMPKSED EEGWKKFCLG EKLCADGAVG PATNESPGID YVQIGFPPLL
   181  SIVSRMNQAT VTSVLEYLSN WFGERDFTPE LGRWLYALLA CLEKPLLPEA HSLIRQLARR
   241  CSEVRLLVDS KDDERVPALN LLICLVSRYF DQRDLADEPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GEMIN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 12 nTPM
  • bone marrow: 9.9 nTPM
  • lymph node: 8.8 nTPM
  • thymus: 8.7 nTPM
  • cerebellum: 7.9 nTPM
  • tonsil: 7.7 nTPM

Single-cell type

  • oocytes: 74 nCPM
  • late spermatids: 65 nCPM
  • early spermatids: 59 nCPM
  • late primary spermatocytes: 39 nCPM
  • early primary spermatocytes: 27 nCPM
  • hepatic stellate cells: 26 nCPM

Immune cell

  • myeloid DC: 16 nTPM
  • plasmacytoid DC: 16 nTPM
  • naive B-cell: 15 nTPM
  • memory B-cell: 15 nTPM
  • naive CD8 T-cell: 14 nTPM
  • gdT-cell: 13 nTPM

Brain region

  • cerebellum: 35 nTPM
  • white matter: 24 nTPM
  • choroid plexus: 24 nTPM
  • cerebral cortex: 23 nTPM
  • basal ganglia: 22 nTPM
  • amygdala: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.02
gnomAD pLI
0
gnomAD missense Z
-0.12
DepMap mean gene effect
-0.65
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Gem-associated protein 2
  • Gemin2/Brr1
  • Survival motor neuron (SMN) interacting protein 1 (SIP1)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GEMIN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GEMIN2 as an antibody target. Whether an autoantibody or antibody against GEMIN2 could matter depends on whether native GEMIN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GEMIN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GEMIN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GEMIN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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