Seroatlas · Human Serome Atlas

CLNS1A

Methylosome subunit pICln

Also known as: CLCI, ICln, ICLN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P54105
Gene
CLNS1A
Ensembl
ENSG00000074201
Chromosome
11
Canonical length
237 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Microtubules,Primary cilium,Cytosol,Connecting piece,Mid piece,Principal piece

OverviewNCBI Gene

This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

237 residues, UniProt reviewed canonical sequence.

>P54105|CLNS1A
     1  MSFLKSFPPP GPAEGLLRQQ PDTEAVLNGK GLGTGTLYIA ESRLSWLDGS GLGFSLEYPT
    61  ISLHALSRDR SDCLGEHLYV MVNAKFEEES KEPVADEEEE DSDDDVEPIT EFRFVPSDKS
   121  ALEAMFTAMC ECQALHPDPE DEDSDDYDGE EYDVEAHEQG QGDIPTFYTY EEGLSHLTAE
   181  GQATLERLEG MLSQSVSSQY NMAGVRTEDS IRDYEDGMEV DTTPTVAGQF EDADVDH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLNS1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
107 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 107 nTPM
  • spinal cord: 99 nTPM
  • tonsil: 99 nTPM
  • liver: 99 nTPM
  • thymus: 96 nTPM
  • choroid plexus: 95 nTPM

Single-cell type

  • esophageal basal cells: 287 nCPM
  • müller glia: 214 nCPM
  • esophageal suprabasal cells: 212 nCPM
  • migrating cytotrophoblasts: 208 nCPM
  • early primary spermatocytes: 196 nCPM
  • gastric progenitor cells: 190 nCPM

Immune cell

  • myeloid DC: 139 nTPM
  • intermediate monocyte: 107 nTPM
  • total PBMC: 106 nTPM
  • NK-cell: 102 nTPM
  • classical monocyte: 101 nTPM
  • naive B-cell: 100 nTPM

Brain region

  • hypothalamus: 94 nTPM
  • white matter: 91 nTPM
  • spinal cord: 86 nTPM
  • basal ganglia: 85 nTPM
  • medulla oblongata: 83 nTPM
  • cerebellum: 82 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0.08
gnomAD missense Z
0.88
DepMap mean gene effect
-1.41
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLNS1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLNS1A as an antibody target. Whether an autoantibody or antibody against CLNS1A could matter depends on whether native CLNS1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLNS1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CLNS1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLNS1A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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