LSM2
U6 snRNA-associated Sm-like protein LSm2
Also known as: C6orf28, G7b, LSM2_HUMAN, YBL026W
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y333
- Gene
- LSM2
- Ensembl
- ENSG00000204392
- Chromosome
- 6
- Canonical length
- 95 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011]
Canonical amino-acid sequenceUniProt
95 residues, UniProt reviewed canonical sequence.
>Q9Y333|LSM2
1 MLFYSFFKSL VGKDVVVELK NDLSICGTLH SVDQYLNIKL TDISVTDPEK YPHMLSVKNC
61 FIRGSVVRYV QLPADEVDTQ LLQDAARKEA LQQKQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LSM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 45 nTPM
Expression across tissuesHPA
Tissue
- cervix: 45 nTPM
- endometrium: 45 nTPM
- kidney: 44 nTPM
- skeletal muscle: 44 nTPM
- spleen: 43 nTPM
- spinal cord: 42 nTPM
Single-cell type
- oligodendrocytes: 26 nCPM
- mucous neck cells: 16 nCPM
- parietal cells: 16 nCPM
- endometrial secretory cells: 13 nCPM
- microglia: 13 nCPM
- bergmann glia: 13 nCPM
Immune cell
- total PBMC: 58 nTPM
- memory CD4 T-cell: 52 nTPM
- naive CD4 T-cell: 46 nTPM
- MAIT T-cell: 45 nTPM
- intermediate monocyte: 38 nTPM
- gdT-cell: 37 nTPM
Brain region
- spinal cord: 28 nTPM
- thalamus: 24 nTPM
- white matter: 23 nTPM
- medulla oblongata: 22 nTPM
- basal ganglia: 20 nTPM
- pons: 20 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.74
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.83
- DepMap mean gene effect
- -2.29
- DepMap dependency class
- pan
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Sm domain, eukaryotic/archaea-type
- LSM domain superfamily
- Sm domain
- LSM domain
- U6 snRNA-associated Sm-like protein LSm2
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of LSM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LSM2 as an antibody target. Whether an autoantibody or antibody against LSM2 could matter depends on whether native LSM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LSM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label LSM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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