Seroatlas · Human Serome Atlas

TDRD3

Tudor domain-containing protein 3

Also known as: FLJ21007, TDRD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H7E2
Gene: TDRD3
Ensembl: ENSG00000083544
Chromosome: 13
Canonical length: 651 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Enables chromatin binding activity; methylated histone binding activity; and transcription coactivator activity. Predicted to be involved in DNA topological change. Located in Golgi apparatus; cytosol; and nucleus. Part of DNA topoisomerase III-beta-TDRD3 complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

651 residues, UniProt reviewed canonical sequence.

>Q9H7E2|TDRD3
     1  MLRLQMTDGH ISCTAVEFSY MSKISLNTPP GTKVKLSGIV DIKNGFLLLN DSNTTVLGGE
    61  VEHLIEKWEL QRSLSKHNRS NIGTEGGPPP FVPFGQKCVS HVQVDSRELD RRKTLQVTMP
   121  VKPTNDNDEF EKQRTAAIAE VAKSKETKTF GGGGGGARSN LNMNAAGNRN REVLQKEKST
   181  KSEGKHEGVY RELVDEKALK HITEMGFSKE ASRQALMDNG NNLEAALNVL LTSNKQKPVM
   241  GPPLRGRGKG RGRIRSEDEE DLGNARPSAP STLFDFLESK MGTLNVEEPK SQPQQLHQGQ
   301  YRSSNTEQNG VKDNNHLRHP PRNDTRQPRN EKPPRFQRDS QNSKSVLEGS GLPRNRGSER
   361  PSTSSVSEVW AEDRIKCDRP YSRYDRTKDT SYPLGSQHSD GAFKKRDNSM QSRSGKGPSF
   421  AEAKENPLPQ GSVDYNNQKR GKRESQTSIP DYFYDRKSQT INNEAFSGIK IEKHFNVNTD
   481  YQNPVRSNSF IGVPNGEVEM PLKGRRIGPI KPAGPVTAVP CDDKIFYNSG PKRRSGPIKP
   541  EKILESSIPM EYAKMWKPGD ECFALYWEDN KFYRAEVEAL HSSGMTAVVK FIDYGNYEEV
   601  LLSNIKPIQT EAWEEEGTYD QTLEFRRGGD GQPRRSTRPT QQFYQPPRAR N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TDRD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 19 nTPM
tongue: 17 nTPM
skeletal muscle: 16 nTPM
ovary: 13 nTPM
pancreas: 13 nTPM
lung: 12 nTPM

Single-cell type

myonuclei: 476 nCPM
mast cells: 294 nCPM
choroid plexus epithelial cells: 291 nCPM
ependymal cells: 267 nCPM
bergmann glia: 234 nCPM
distal convoluted tubule cells: 231 nCPM

Immune cell

plasmacytoid DC: 4.6 nTPM
T-reg: 4.5 nTPM
naive CD8 T-cell: 3.8 nTPM
memory CD4 T-cell: 3.7 nTPM
memory CD8 T-cell: 3.7 nTPM
gdT-cell: 3.2 nTPM

Brain region

white matter: 44 nTPM
thalamus: 39 nTPM
basal ganglia: 39 nTPM
cerebellum: 39 nTPM
medulla oblongata: 37 nTPM
cerebral cortex: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0
gnomAD missense Z: 1.43
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

DNA topological change

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tudor domain
UBA-like superfamily
RecQ mediated genome instability protein 1, OB-fold domain
Ubiquitin-associated domain
RecQ mediated genome instability protein, N-terminal OB-fold domain superfamily
Tudor domain
RMI1, N-terminal OB-fold domain
UBA-like domain
Tudor domain-containing protein 3, UBA domain
Tudor domain-containing protein 3, Tudor domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TDRD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TDRD3 as an antibody target. Whether an autoantibody or antibody against TDRD3 could matter depends on whether native TDRD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TDRD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TDRD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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