Seroatlas · Human Serome Atlas

CD2BP2

CD2 antigen cytoplasmic tail-binding protein 2

Also known as: CD2B2_HUMAN, LIN1, PPP1R59, Snu40, U5-52K

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95400
Gene
CD2BP2
Ensembl
ENSG00000169217
Chromosome
16
Canonical length
341 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles,Cytosol

OverviewNCBI Gene

This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008]

Canonical amino-acid sequenceUniProt

341 residues, UniProt reviewed canonical sequence.

>O95400|CD2BP2
     1  MPKRKVTFQG VGDEEDEDEI IVPKKKLVDP VAGSGGPGSR FKGKHSLDSD EEEDDDDGGS
    61  SKYDILASED VEGQEAATLP SEGGVRITPF NLQEEMEEGH FDADGNYFLN RDAQIRDSWL
   121  DNIDWVKIRE RPPGQRQASD SEEEDSLGQT SMSAQALLEG LLELLLPRET VAGALRRLGA
   181  RGGGKGRKGP GQPSSPQRLD RLSGLADQMV ARGNLGVYQE TRERLAMRLK GLGCQTLGPH
   241  NPTPPPSLDM FAEELAEEEL ETPTPTQRGE AESRGDGLVD VMWEYKWENT GDAELYGPFT
   301  SAQMQTWVSE GYFPDGVYCR KLDPPGGQFY NSKRIDFDLY T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD2BP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
47 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 47 nTPM
  • spleen: 44 nTPM
  • skeletal muscle: 44 nTPM
  • tonsil: 41 nTPM
  • thyroid gland: 41 nTPM
  • pituitary gland: 40 nTPM

Single-cell type

  • esophageal apical cells: 124 nCPM
  • megakaryocytes: 118 nCPM
  • syncytiotrophoblasts: 111 nCPM
  • decidual stromal cells: 86 nCPM
  • hofbauer cells: 86 nCPM
  • esophageal suprabasal cells: 76 nCPM

Immune cell

  • neutrophil: 122 nTPM
  • eosinophil: 117 nTPM
  • basophil: 108 nTPM
  • non-classical monocyte: 103 nTPM
  • naive B-cell: 98 nTPM
  • T-reg: 95 nTPM

Brain region

  • white matter: 42 nTPM
  • medulla oblongata: 42 nTPM
  • hypothalamus: 41 nTPM
  • cerebral cortex: 41 nTPM
  • midbrain: 39 nTPM
  • thalamus: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.04
gnomAD pLI
0
gnomAD missense Z
-0.56
DepMap mean gene effect
-0.27
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD2BP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD2BP2 as an antibody target. Whether an autoantibody or antibody against CD2BP2 could matter depends on whether native CD2BP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD2BP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CD2BP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD2BP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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