Seroatlas · Human Serome Atlas

LSM7

U6 snRNA-associated Sm-like protein LSm7

Also known as: LSM7_HUMAN, YNL147W

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UK45
Gene
LSM7
Ensembl
ENSG00000130332
Chromosome
19
Canonical length
103 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli fibrillar center

OverviewNCBI Gene

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

103 residues, UniProt reviewed canonical sequence.

>Q9UK45|LSM7
     1  MADKEKKKKE SILDLSKYID KTIRVKFQGG REASGILKGF DPLLNLVLDG TIEYMRDPDD
    61  QYKLTEDTRQ LGLVVCRGTS VVLICPQDGM EAIPNPFIQQ QDA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LSM7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
105 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 105 nTPM
  • esophagus: 96 nTPM
  • spinal cord: 96 nTPM
  • amygdala: 90 nTPM
  • spleen: 89 nTPM
  • pituitary gland: 87 nTPM

Single-cell type

  • esophageal basal cells: 491 nCPM
  • migrating cytotrophoblasts: 472 nCPM
  • cytotrophoblasts: 445 nCPM
  • oocytes: 396 nCPM
  • extravillous trophoblasts: 393 nCPM
  • esophageal suprabasal cells: 359 nCPM

Immune cell

  • memory B-cell: 471 nTPM
  • naive B-cell: 413 nTPM
  • plasmacytoid DC: 292 nTPM
  • myeloid DC: 280 nTPM
  • intermediate monocyte: 246 nTPM
  • T-reg: 244 nTPM

Brain region

  • white matter: 39 nTPM
  • hypothalamus: 33 nTPM
  • medulla oblongata: 33 nTPM
  • midbrain: 33 nTPM
  • cerebellum: 32 nTPM
  • spinal cord: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LSM7.

Disease | AllUniProt

Conditions LSM7 is implicated in, by any mechanism.

  • Leukodystrophy and cerebellar atrophy (LDCA) MIM:621191

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 18 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0.46
gnomAD missense Z
1.43
DepMap mean gene effect
-1.83
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LSM7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LSM7 as an antibody target. Whether an autoantibody or antibody against LSM7 could matter depends on whether native LSM7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LSM7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LSM7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LSM7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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