Seroatlas · Human Serome Atlas

LSM8

U6 snRNA-associated Sm-like protein LSm8

Also known as: LSM8_HUMAN, YJR022W

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95777
Gene: LSM8
Ensembl: ENSG00000128534
Chromosome: 7
Canonical length: 96 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a member of the like-Sm family of proteins. The encoded protein consists of a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. This protein partners with six paralogs to form a heteroheptameric ring which transiently binds U6 small nuclear RNAs and is involved in the general maturation of RNA in the nucleus. [provided by RefSeq, Jan 2010]

Canonical amino-acid sequenceUniProt

96 residues, UniProt reviewed canonical sequence.

>O95777|LSM8
     1  MTSALENYIN RTVAVITSDG RMIVGTLKGF DQTINLILDE SHERVFSSSQ GVEQVVLGLY
    61  IVRGDNVAVI GEIDEETDSA LDLGNIRAEP LNSVAH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LSM8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 42 nTPM
lymph node: 27 nTPM
tonsil: 26 nTPM
spleen: 24 nTPM
appendix: 21 nTPM
pancreas: 20 nTPM

Single-cell type

gastric progenitor cells: 263 nCPM
extravillous trophoblasts: 249 nCPM
esophageal basal cells: 212 nCPM
hofbauer cells: 195 nCPM
migrating cytotrophoblasts: 176 nCPM
cytotrophoblasts: 161 nCPM

Immune cell

plasmacytoid DC: 94 nTPM
memory CD8 T-cell: 76 nTPM
T-reg: 75 nTPM
memory B-cell: 68 nTPM
memory CD4 T-cell: 68 nTPM
naive CD8 T-cell: 68 nTPM

Brain region

cerebellum: 37 nTPM
white matter: 24 nTPM
basal ganglia: 20 nTPM
pons: 19 nTPM
cerebral cortex: 19 nTPM
medulla oblongata: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: -1.81
DepMap dependency class: pan

OntologyGO

Biological processes

via spliceosome
mRNA splicing

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Sm domain, eukaryotic/archaea-type
LSM domain superfamily
U6 snRNA-associated Sm-like protein Lsm1/8
Sm domain
LSM domain
Sm-like protein Lsm8

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LSM8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LSM8 as an antibody target. Whether an autoantibody or antibody against LSM8 could matter depends on whether native LSM8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LSM8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LSM8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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