Seroatlas · Human Serome Atlas

GEMIN6

Gem-associated protein 6

Also known as: FLJ23459, GEMI6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WXD5
Gene: GEMIN6
Ensembl: ENSG00000152147
Chromosome: 2
Canonical length: 167 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM, Jul 2002]

Canonical amino-acid sequenceUniProt

167 residues, UniProt reviewed canonical sequence.

>Q8WXD5|GEMIN6
     1  MSEWMKKGPL EWQDYIYKEV RVTASEKNEY KGWVLTTDPV SANIVLVNFL EDGSMSVTGI
    61  MGHAVQTVET MNEGDHRVRE KLMHLFTSGD CKAYSPEDLE ERKNSLKKWL EKNHIPITEQ
   121  GDAPRTLCVA GVLTIDPPYG PENCSSSNEI ILSRVQDLIE GHLTASQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GEMIN6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

testis: 19 nTPM
choroid plexus: 13 nTPM
liver: 13 nTPM
kidney: 12 nTPM
tonsil: 12 nTPM
skeletal muscle: 11 nTPM

Single-cell type

late primary spermatocytes: 287 nCPM
early spermatids: 131 nCPM
late spermatids: 61 nCPM
decidual stromal cells: 47 nCPM
extravillous trophoblasts: 47 nCPM
migrating cytotrophoblasts: 44 nCPM

Immune cell

memory B-cell: 32 nTPM
T-reg: 31 nTPM
naive B-cell: 29 nTPM
intermediate monocyte: 29 nTPM
non-classical monocyte: 27 nTPM
NK-cell: 26 nTPM

Brain region

white matter: 17 nTPM
cerebral cortex: 13 nTPM
cerebellum: 13 nTPM
basal ganglia: 13 nTPM
choroid plexus: 13 nTPM
thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: -1.92
DepMap mean gene effect: -0.8
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

AD domain
Sm domain
Gem-associated protein 6
Gem-associated protein 6, C-terminal domain
Gem-associated protein 6, Sm-like domain
Gemin6 Sm-like domain
Gemin6 C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GEMIN6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GEMIN6 as an antibody target. Whether an autoantibody or antibody against GEMIN6 could matter depends on whether native GEMIN6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GEMIN6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GEMIN6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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