Seroatlas · Human Serome Atlas

SGF29

SAGA-associated factor 29

Also known as: CCDC101, FLJ32446, SGF29_HUMAN, TDRD29

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96ES7
Gene
SGF29
Ensembl
ENSG00000176476
Chromosome
16
Canonical length
293 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]

Canonical amino-acid sequenceUniProt

293 residues, UniProt reviewed canonical sequence.

>Q96ES7|SGF29
     1  MALVSADSRI AELLTELHQL IKQTQEERSR SEHNLVNIQK THERMQTENK ISPYYRTKLR
    61  GLYTTAKADA EAECNILRKA LDKIAEIKSL LEERRIAAKI AGLYNDSEPP RKTMRRGVLM
   121  TLLQQSAMTL PLWIGKPGDK PPPLCGAIPA SGDYVARPGD KVAARVKAVD GDEQWILAEV
   181  VSYSHATNKY EVDDIDEEGK ERHTLSRRRV IPLPQWKANP ETDPEALFQK EQLVLALYPQ
   241  TTCFYRALIH APPQRPQDDY SVLFEDTSYA DGYSPPLNVA QRYVVACKEP KKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SGF29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 49 nTPM
  • testis: 41 nTPM
  • ovary: 32 nTPM
  • endometrium: 29 nTPM
  • cervix: 26 nTPM
  • colon: 26 nTPM

Single-cell type

  • late spermatids: 524 nCPM
  • oocytes: 359 nCPM
  • early spermatids: 271 nCPM
  • late primary spermatocytes: 73 nCPM
  • ovarian stromal cells: 57 nCPM
  • undifferentiated spermatogonia: 55 nCPM

Immune cell

  • naive CD4 T-cell: 85 nTPM
  • T-reg: 79 nTPM
  • memory CD4 T-cell: 75 nTPM
  • plasmacytoid DC: 72 nTPM
  • naive CD8 T-cell: 67 nTPM
  • naive B-cell: 66 nTPM

Brain region

  • cerebellum: 15 nTPM
  • white matter: 14 nTPM
  • basal ganglia: 11 nTPM
  • medulla oblongata: 11 nTPM
  • hypothalamus: 11 nTPM
  • pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0
DepMap mean gene effect
-0.46
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • SGF29 tudor-like domain
  • SAGA-associated factor 29
  • SAGA-associated factor 29, second Tudor domain
  • SAGA-associated factor 29, first Tudor domain
  • SGF29 tudor-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SGF29 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SGF29 as an antibody target. Whether an autoantibody or antibody against SGF29 could matter depends on whether native SGF29 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SGF29 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SGF29 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SGF29. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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