DR1

Protein identityUniProt · HPA

UniProt accession

Q01658

Gene

DR1

Ensembl

ENSG00000117505

Chromosome

1

Canonical length

176 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm

Quaternary structure

Homotetramer

OverviewNCBI Gene

This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

176 residues, UniProt reviewed canonical sequence.

>Q01658|DR1
     1  MASSSGNDDD LTIPRAAINK MIKETLPNVR VANDARELVV NCCTEFIHLI SSEANEICNK
    61  SEKKTISPEH VIQALESLGF GSYISEVKEV LQECKTVALK RRKASSRLEN LGIPEEELLR
   121  QQQELFAKAR QQQAELAQQE WLQMQQAAQQ AQLAAASASA SNQAGSSQDE EDDDDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

56 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.37

gnomAD pLI

0.92

gnomAD missense Z

2.23

DepMap mean gene effect

-0.88

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of transcription by RNA polymerase II
• regulation of cell cycle
• regulation of cell division
• regulation of DNA-templated transcription
• regulation of embryonic development
• regulation of transcription by RNA polymerase II
• RNA polymerase II preinitiation complex assembly

Molecular functions

• DNA binding
• protein heterodimerization activity
• RNA polymerase II general transcription initiation factor activity
• TBP-class protein binding

Cellular components

• ATAC complex
• mitotic spindle
• negative cofactor 2 complex
• nucleoplasm
• RNA polymerase II transcription regulator complex

Protein domainsUniProt · Pfam · InterPro

• Transcription factor CBF/NF-Y/archaeal histone domain
• Histone-fold
• Histone-like transcription factor (CBF/NF-Y) and archaeal histone
• Negative cofactor 2 complex subunit beta

KeywordsUniProt

• Acetylation
• DNA-binding
• Nucleus
• Phosphoprotein
• Repressor
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of DR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NFIL3
• TBP
• DRAP1
• MBIP
• POLE3
• SGF29
• YEATS2