Seroatlas · Human Serome Atlas

TAF12

Transcription initiation factor TFIID subunit 12

Also known as: TAF12_HUMAN, TAF2J, TAFII20

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16514
Gene: TAF12
Ensembl: ENSG00000120656
Chromosome: 1
Canonical length: 161 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

161 residues, UniProt reviewed canonical sequence.

>Q16514|TAF12
     1  MNQFGPSALI NLSNFSSIKP EPASTPPQGS MANSTAVVKI PGTPGAGGRL SPENNQVLTK
    61  KKLQDLVREV DPNEQLDEDV EEMLLQIADD FIESVVTAAC QLARHRKSST LEVKDVQLHL
   121  ERQWNMWIPG FGSEEIRPYK KACTTEAHKQ RMALIRKTTK K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAF12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 83 nTPM

Expression across tissuesHPA

Tissue

cervix: 83 nTPM
tonsil: 42 nTPM
thymus: 38 nTPM
seminal vesicle: 38 nTPM
epididymis: 37 nTPM
lymph node: 37 nTPM

Single-cell type

early primary spermatocytes: 333 nCPM
differentiating spermatogonia: 199 nCPM
syncytiotrophoblasts: 154 nCPM
myonuclei: 147 nCPM
esophageal apical cells: 143 nCPM
neutrophils: 139 nCPM

Immune cell

eosinophil: 123 nTPM
neutrophil: 121 nTPM
basophil: 112 nTPM
T-reg: 56 nTPM
NK-cell: 56 nTPM
classical monocyte: 54 nTPM

Brain region

choroid plexus: 30 nTPM
cerebellum: 30 nTPM
white matter: 27 nTPM
cerebral cortex: 27 nTPM
medulla oblongata: 27 nTPM
thalamus: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.95
gnomAD missense Z: 1.29
DepMap mean gene effect: -0.81
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Histone-fold
Transcription initiation factor TFIID subunit 12 domain
Transcription initiation factor TFIID subunit 12
Transcription initiation factor TFIID subunit A

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TAF12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAF12 as an antibody target. Whether an autoantibody or antibody against TAF12 could matter depends on whether native TAF12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAF12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAF12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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