Seroatlas · Human Serome Atlas

MBIP

MAP3K12-binding inhibitory protein 1

Also known as: MBIP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NS73
Gene: MBIP
Ensembl: ENSG00000151332
Chromosome: 14
Canonical length: 344 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Enables identical protein binding activity and protein kinase inhibitor activity. Involved in several processes, including positive regulation of JNK cascade; regulation of cell division; and regulation of gene expression. Located in cytosol; nucleolus; and nucleoplasm. Part of ATAC complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>Q9NS73|MBIP
     1  MAAATELNRP SSGDRNLERR CRPNLSREVL YEIFRSLHTL VGQLDLRDDV VKITIDWNKL
    61  QSLSAFQPAL LFSALEQHIL YLQPFLAKLQ SPIKEENTTA VEEIGRTEMG NKNEVNDKFS
   121  IGDLQEEEKH KESDLRDVKK TQIHFDPEVV QIKAGKAEID RRISAFIERK QAEINENNVR
   181  EFCNVIDCNQ ENSCARTDAI FTPYPGFKSH VKVSRVVNTY GPQTRPEGIP GSGHKPNSML
   241  RDCGNQAVEE RLQNIEAHLR LQTGGPVPRD IYQRIKKLED KILELEGISP EYFQSVSFSG
   301  KRRKVQPPQQ NYSLAELDEK ISALKQALLR KSREAESMAT HHLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MBIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 77 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 77 nTPM
lung: 72 nTPM
bone marrow: 33 nTPM
stomach: 30 nTPM
ovary: 29 nTPM
liver: 27 nTPM

Single-cell type

alveolar cells type 2: 422 nCPM
transitional alveolar cells: 325 nCPM
pituicytes/fscs: 243 nCPM
alveolar cells type 1: 176 nCPM
parietal cells: 154 nCPM
oocytes: 101 nCPM

Immune cell

T-reg: 24 nTPM
naive CD4 T-cell: 23 nTPM
MAIT T-cell: 19 nTPM
naive CD8 T-cell: 19 nTPM
memory CD8 T-cell: 18 nTPM
memory CD4 T-cell: 18 nTPM

Brain region

white matter: 29 nTPM
cerebellum: 28 nTPM
hypothalamus: 26 nTPM
basal ganglia: 23 nTPM
choroid plexus: 22 nTPM
cerebral cortex: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 0.14
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MBIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MBIP as an antibody target. Whether an autoantibody or antibody against MBIP could matter depends on whether native MBIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MBIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MBIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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