Seroatlas · Human Serome Atlas

TAF9B

Transcription initiation factor TFIID subunit 9B

Also known as: DN-7, DN7, TAF9B_HUMAN, TAF9L, TAFII31L, TFIID-31

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HBM6
Gene: TAF9B
Ensembl: ENSG00000187325
Chromosome: X
Canonical length: 251 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

251 residues, UniProt reviewed canonical sequence.

>Q9HBM6|TAF9B
     1  MESGKMAPPK NAPRDALVMA QILKDMGITE YEPRVINQML EFAFRYVTTI LDDAKIYSSH
    61  AKKPNVDADD VRLAIQCRAD QSFTSPPPRD FLLDIARQKN QTPLPLIKPY AGPRLPPDRY
   121  CLTAPNYRLK SLIKKGPNQG RLVPRLSVGA VSSKPTTPTI ATPQTVSVPN KVATPMSVTS
   181  QRFTVQIPPS QSTPVKPVPA TTAVQNVLIN PSMIGPKNIL ITTNMVSSQN TANEANPLKR
   241  KHEDDDDNDI M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAF9B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

retina: 31 nTPM
smooth muscle: 29 nTPM
cerebral cortex: 23 nTPM
heart muscle: 22 nTPM
endometrium: 22 nTPM
parathyroid gland: 22 nTPM

Single-cell type

oocytes: 83 nCPM
differentiating spermatogonia: 38 nCPM
smooth muscle cells: 25 nCPM
undifferentiated spermatogonia: 23 nCPM
cytotrophoblasts: 22 nCPM
esophageal basal cells: 22 nCPM

Immune cell

T-reg: 18 nTPM
memory CD4 T-cell: 15 nTPM
naive CD4 T-cell: 15 nTPM
NK-cell: 14 nTPM
MAIT T-cell: 13 nTPM
memory CD8 T-cell: 12 nTPM

Brain region

white matter: 33 nTPM
hypothalamus: 28 nTPM
spinal cord: 26 nTPM
cerebral cortex: 26 nTPM
medulla oblongata: 25 nTPM
basal ganglia: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -0.11
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TAF9B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAF9B as an antibody target. Whether an autoantibody or antibody against TAF9B could matter depends on whether native TAF9B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAF9B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAF9B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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